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Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

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dc.contributor.author Gassmann, Norina-N.
dc.contributor.author van-Elteren, Hugo-A.
dc.contributor.author Goos, Tom-G.
dc.contributor.author Morales, Claudia-R.
dc.contributor.author Rivera Chira, Maria Concepcion
dc.contributor.author Martin, Daniel-S.
dc.contributor.author Cabala-Peralta, Patricia
dc.contributor.author Passano-Del-Carpio, Agustin
dc.contributor.author Aranibar-Machaca, Saul
dc.contributor.author Huicho Oriundo, Luis
dc.contributor.author Reiss, Irwin-K. M.
dc.contributor.author Gassmann, Max
dc.contributor.author de-Jonge, Rogier-C. J.
dc.date.accessioned 2019-02-06T14:45:34Z
dc.date.available 2019-02-06T14:45:34Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5067
dc.description.abstract The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm(2); P </= 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level. en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartofseries Journal of Applied Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject hypoxia en_US
dc.subject incident dark field imaging en_US
dc.subject microcirculation en_US
dc.subject near infrared spectroscopy en_US
dc.subject neonates en_US
dc.subject oxygen profiling en_US
dc.subject Acclimatization/physiology en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Infant, Newborn/physiology en_US
dc.subject Male en_US
dc.subject Microcirculation/physiology en_US
dc.subject Microvessels/anatomy & histology/physiology en_US
dc.subject Peru en_US
dc.subject Pregnancy/physiology en_US
dc.subject Prospective Studies en_US
dc.subject Young Adult en_US
dc.title Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/japplphysiol.00561.2016
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1522-1601


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