Universidad Peruana Cayetano Heredia

Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus

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dc.contributor.author Herbst-de-Cortina, S.
dc.contributor.author Bristow, C. C.
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Perez, D. G.
dc.contributor.author Konda, K. A.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, J. D.
dc.date.accessioned 2019-02-06T14:45:35Z
dc.date.available 2019-02-06T14:45:35Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5081
dc.description.abstract Combining the detection of syphilis and HIV antibodies into one point-of-care test integrates syphilis screening into already existing HIV screening programs, which may be particularly beneficial in settings such as antenatal care. Using the INSTI Multiplex downward-flow immunoassay, we tested 200 stored serum samples from high-risk patients enrolled in a longitudinal study on HIV infection and syphilis in Peruvian men who have sex with men and transgender women. This rapid assay detected HIV and Treponema pallidum serum antibodies with sensitivities of 100% (95% confidence interval [CI], 95.9% to 100%) and 87.4% (95% CI, 81.4% to 92.0%), respectively, and specificities of 95.5% (95% CI, 89.9% to 98.5%) and 97.0% (95% CI, 84.2% to 99.9%), respectively (n = 200). The sensitivity for syphilis antibody detection was higher in patients with a rapid plasma reagin titer of >/=1:8 (97.3%) than in those with a titer of </=1:4 (90%) or a nonreactive titer (66.7%). en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Journal of Clinical Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Point-of-Care Systems en_US
dc.subject Antibodies, Bacterial/blood en_US
dc.subject Clinical Laboratory Techniques/methods en_US
dc.subject Female en_US
dc.subject HIV Antibodies/blood en_US
dc.subject HIV Infections/diagnosis en_US
dc.subject HIV/immunology en_US
dc.subject Humans en_US
dc.subject Immunoassay/methods en_US
dc.subject Longitudinal Studies en_US
dc.subject Male en_US
dc.subject Peru en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Syphilis/diagnosis en_US
dc.subject Transgender Persons en_US
dc.subject Treponema pallidum/immunology en_US
dc.title Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/JCM.00637-16
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1098-660X


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