Effect of butanolic fraction of yellow and black maca (Lepidium meyenii) on the sperm count of adult mice

Gonzales Rengifo, Gustavo Francisco; Inoue, N.; Farfan, C.

dc.contributor.author	Inoue, N.
dc.contributor.author	Farfan, C.
dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned	2019-02-06T14:45:35Z
dc.date.available	2019-02-06T14:45:35Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5090
dc.description.abstract	Lepidium meyenii, known as maca, is a popular nutraceutical food which is grown over 4,000 m above sea level in the Peruvian central highlands. Maca contains alkaloids, but there are no studies on their biological effects. The butanol fraction obtained from methanol extract of maca hypocotyls contains alkaloids. The effects of butanol/aqueous fractions partitioned from methanol extract of yellow and black maca were examined. Total phenolic content (TPC) and antioxidant capacity by 2,2'-diphenyl-1-picrylhydrazyl were used to evaluate maca fractions in vitro. Daily sperm production and sperm count in epididymis and vas deferens in mice were determined as biological effect of maca extracts in vivo. Yellow maca (21.7%+/-0.69) had better antioxidant capacity than black maca (18.2% +/- 0.12; p < .01). Antioxidant activity was better in the methanolic fraction than in the aqueous fraction of yellow or black maca. TPC is higher in the aqueous fraction than in the methanolic extract of yellow or black maca. Black maca administration resulted in higher concentration of sperm count in epididymis and vas deferens compared to yellow maca. A higher biological effect was observed in methanolic extract and in aqueous extract than in the butanol fraction of maca. In conclusion, better biological effect was observed in the methanolic extract of maca than in its partitioned fractions.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Lepidium	en_US
dc.subject	Animals	en_US
dc.subject	antioxidant	en_US
dc.subject	Antioxidants/pharmacology	en_US
dc.subject	black maca	en_US
dc.subject	butanolic fraction	en_US
dc.subject	Epididymis	en_US
dc.subject	Male	en_US
dc.subject	Mice	en_US
dc.subject	Plant Extracts/pharmacology	en_US
dc.subject	sperm count	en_US
dc.subject	Sperm Count	en_US
dc.subject	Spermatozoa/drug effects	en_US
dc.subject	total phenolic content	en_US
dc.subject	Vas Deferens	en_US
dc.subject	yellow maca	en_US
dc.title	Effect of butanolic fraction of yellow and black maca (Lepidium meyenii) on the sperm count of adult mice	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/and.12679
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn	1439-0272