Universidad Peruana Cayetano Heredia

Effect of butanolic fraction of yellow and black maca (Lepidium meyenii) on the sperm count of adult mice

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dc.contributor.author Inoue, N.
dc.contributor.author Farfan, C.
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2019-02-06T14:45:35Z
dc.date.available 2019-02-06T14:45:35Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5090
dc.description.abstract Lepidium meyenii, known as maca, is a popular nutraceutical food which is grown over 4,000 m above sea level in the Peruvian central highlands. Maca contains alkaloids, but there are no studies on their biological effects. The butanol fraction obtained from methanol extract of maca hypocotyls contains alkaloids. The effects of butanol/aqueous fractions partitioned from methanol extract of yellow and black maca were examined. Total phenolic content (TPC) and antioxidant capacity by 2,2'-diphenyl-1-picrylhydrazyl were used to evaluate maca fractions in vitro. Daily sperm production and sperm count in epididymis and vas deferens in mice were determined as biological effect of maca extracts in vivo. Yellow maca (21.7%+/-0.69) had better antioxidant capacity than black maca (18.2% +/- 0.12; p < .01). Antioxidant activity was better in the methanolic fraction than in the aqueous fraction of yellow or black maca. TPC is higher in the aqueous fraction than in the methanolic extract of yellow or black maca. Black maca administration resulted in higher concentration of sperm count in epididymis and vas deferens compared to yellow maca. A higher biological effect was observed in methanolic extract and in aqueous extract than in the butanol fraction of maca. In conclusion, better biological effect was observed in the methanolic extract of maca than in its partitioned fractions. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Andrologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Lepidium en_US
dc.subject Animals en_US
dc.subject antioxidant en_US
dc.subject Antioxidants/pharmacology en_US
dc.subject black maca en_US
dc.subject butanolic fraction en_US
dc.subject Epididymis en_US
dc.subject Male en_US
dc.subject Mice en_US
dc.subject Plant Extracts/pharmacology en_US
dc.subject sperm count en_US
dc.subject Sperm Count en_US
dc.subject Spermatozoa/drug effects en_US
dc.subject total phenolic content en_US
dc.subject Vas Deferens en_US
dc.subject yellow maca en_US
dc.title Effect of butanolic fraction of yellow and black maca (Lepidium meyenii) on the sperm count of adult mice en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/and.12679
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn 1439-0272


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