Rickettsial Disease in the Peruvian Amazon Basin

Richards, Allen-L.; Kocher, Claudine; Zevallos, Karine; Galvez, Hugo-A.; Jiang, Ju; Flores-Mendoza, Carmen; Halsey, Eric-S.; Cespedes, Manuel; Leguia, Mariana; Loyola Sosa, Steev Orlando; Ampuero, Julia-S.; Bausch, Daniel-G.; Morrison, Amy-C.; Castillo, Roger-M.; Astete, Helvio

dc.contributor.author	Kocher, Claudine
dc.contributor.author	Morrison, Amy-C.
dc.contributor.author	Leguia, Mariana
dc.contributor.author	Loyola Sosa, Steev Orlando
dc.contributor.author	Castillo, Roger-M.
dc.contributor.author	Galvez, Hugo-A.
dc.contributor.author	Astete, Helvio
dc.contributor.author	Flores-Mendoza, Carmen
dc.contributor.author	Ampuero, Julia-S.
dc.contributor.author	Bausch, Daniel-G.
dc.contributor.author	Halsey, Eric-S.
dc.contributor.author	Cespedes, Manuel
dc.contributor.author	Zevallos, Karine
dc.contributor.author	Jiang, Ju
dc.contributor.author	Richards, Allen-L.
dc.date.accessioned	2019-02-06T14:45:36Z
dc.date.available	2019-02-06T14:45:36Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5093
dc.description.abstract	Using a large, passive, clinic-based surveillance program in Iquitos, Peru, we characterized the prevalence of rickettsial infections among undifferentiated febrile cases and obtained evidence of pathogen transmission in potential domestic reservoir contacts and their ectoparasites. Blood specimens from humans and animals were assayed for spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR) by ELISA and/or PCR; ectoparasites were screened by PCR. Logistic regression was used to determine associations between patient history, demographic characteristics of participants and symptoms, clinical findings and outcome of rickettsial infection. Of the 2,054 enrolled participants, almost 2% showed evidence of seroconversion or a 4-fold rise in antibody titers specific for rickettsiae between acute and convalescent blood samples. Of 190 fleas (Ctenocephalides felis) and 60 ticks (Rhipicephalus sanguineus) tested, 185 (97.4%) and 3 (5%), respectively, were positive for Rickettsia spp. Candidatus Rickettsia asemboensis was identified in 100% and 33% of the fleas and ticks tested, respectively. Collectively, our serologic data indicates that human pathogenic SFGR are present in the Peruvian Amazon and pose a significant risk of infection to individuals exposed to wild, domestic and peri-domestic animals and their ectoparasites.	en_US
dc.language.iso	eng
dc.publisher	Public Library of Science
dc.relation.ispartofseries	PLoS Neglected Tropical Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Adolescent	en_US
dc.subject	Adult	en_US
dc.subject	Animals	en_US
dc.subject	Antibodies, Bacterial/blood	en_US
dc.subject	Child	en_US
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Peru/epidemiology	en_US
dc.subject	Rickettsia Infections/blood/epidemiology/microbiology/transmission	en_US
dc.subject	Rickettsia/genetics/isolation & purification/physiology	en_US
dc.subject	Siphonaptera/classification/microbiology	en_US
dc.subject	Young Adult	en_US
dc.title	Rickettsial Disease in the Peruvian Amazon Basin	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1371/journal.pntd.0004843
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1935-2735