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Blood pressure response to six-minute walk test in hypertensive subjects exposed to high altitude: effects of antihypertensive combination treatment

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dc.contributor.author Lang, Morin
dc.contributor.author Faini, Andrea
dc.contributor.author Caravita, Sergio
dc.contributor.author Bilo, Grzegorz
dc.contributor.author Anza-Ramirez, Cecilia
dc.contributor.author Villafuerte, Francisco-C.
dc.contributor.author Macarlupu, Jose-Luis
dc.contributor.author Salvioni, Elisabetta
dc.contributor.author Agostoni, Piergiuseppe
dc.contributor.author Parati, Gianfranco
dc.date.accessioned 2019-02-06T14:45:36Z
dc.date.available 2019-02-06T14:45:36Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5096
dc.description.abstract Background: Limited evidence exists on blood pressure (BP) responses to exercise in hypertensive subjects exposed to high altitude, and on the effects of antihypertensive treatment in this setting. We aimed to asses BP response to submaximal exercise in hypertensive lowlanders acutely exposed to high altitude, and the effects of a calcium antagonist–angiotensin receptor blocker combination in this condition. Methods: 89 mild-hypertensive participants in HIGHCARE-ANDES study performed a six-minute walk test in 3 conditions: at sea-level off-treatment; at sea-level after 6 weeks of double-blind treatment with telmisartan 80mg + slow release nifedipine 30 mg or with placebo; on the first full day of permanence at 3260 m altitude under randomized treatment. Results: The distance walked in 6 min was reduced by about 10% at high altitude in both groups (p b 0.001) without treatment-related differences. Systolic BP increased at altitude in both groups, remaining lower on telmisartan/nifedipine than on placebo both before and after exercise (p b 0.001).The exercise-induced increase in systolic BP at altitude was blunted by active treatment as compared to placebo (+32.0 ± 19.8 vs +41.9 ± 23.3 mm Hg, p b 0.05). Diastolic BP was unchanged from sea-level to altitude in both groups, showing lower values on telmisartan/nifedipine than on placebo before and after exercise (p b 0.01). Oxygen saturation was similarly reduced in both groups before exercise at altitude, but after exercise it was higher on telmisartan/nifedipine than on placebo. Conclusions: In mild hypertensives, acute exposure to high altitude enhances the BP response to exercise. Such an enhanced response is effectively reduced by telmisartan/nifedipine combination therapy, without affecting exercise performance. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1874-1754
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Adult en_US
dc.subject Antihypertensive Agents/administration & dosage en_US
dc.subject Benzimidazoles/administration & dosage en_US
dc.subject Benzoates/administration & dosage en_US
dc.subject Blood pressure en_US
dc.subject Blood Pressure/drug effects/physiology en_US
dc.subject Double-Blind Method en_US
dc.subject Drug Therapy, Combination en_US
dc.subject Exercise en_US
dc.subject Female en_US
dc.subject High altitude hypoxia en_US
dc.subject Humans en_US
dc.subject Hypertension en_US
dc.subject Hypertension/diagnosis/drug therapy/physiopathology en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Nifedipine/administration & dosage en_US
dc.subject Six-minute walk test en_US
dc.subject Telmisartan en_US
dc.subject Treatment Outcome en_US
dc.subject Walk Test/methods en_US
dc.title Blood pressure response to six-minute walk test in hypertensive subjects exposed to high altitude: effects of antihypertensive combination treatment en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijcard.2016.04.169

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