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Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms

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dc.contributor.author Lazova, Rossitza
dc.contributor.author Seeley, Erin-H.
dc.contributor.author Kutzner, Heinz
dc.contributor.author Scolyer, Richard-A.
dc.contributor.author Scott, Glynis
dc.contributor.author Cerroni, Lorenzo
dc.contributor.author Fried, Isabella
dc.contributor.author Kozovska, Milena-E.
dc.contributor.author Rosenberg, Arlene-S.
dc.contributor.author Prieto, Victor-G.
dc.contributor.author Shehata, Bahig-M.
dc.contributor.author Durham, Megan-M.
dc.contributor.author Henry, Gina
dc.contributor.author Rodriguez-Peralto, Jose-L.
dc.contributor.author Riveiro-Falkenbach, Erica
dc.contributor.author Schaefer, Jochen-T.
dc.contributor.author Danialan, Richard
dc.contributor.author Fraitag, Sylvie
dc.contributor.author Vollenweider-Roten, Sonja
dc.contributor.author Sepehr, Alireza
dc.contributor.author Sangueza, Martin
dc.contributor.author Hijazi, Nouf
dc.contributor.author Corredoira, Yamile
dc.contributor.author Kowal, Rachel
dc.contributor.author Harris, Olga-M.
dc.contributor.author Bravo Puccio, Francisco Gerardo
dc.contributor.author Boyd, Alan-S.
dc.contributor.author Gueorguieva, Ralitza
dc.contributor.author Caprioli, Richard-M.
dc.date.accessioned 2019-02-06T14:45:36Z
dc.date.available 2019-02-06T14:45:36Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5099
dc.description.abstract BACKGROUND: Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. OBJECTIVE: We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. METHODS: We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS. Patients were divided into clinical groups 1 to 4 representing best to worst clinical behavior. The association among IMS findings, histopathological diagnoses, and clinical groups was assessed. RESULTS: There was a strong association between a diagnosis of Spitzoid melanoma by IMS and lesions categorized as clinical groups 2, 3, and 4 (recurrence of disease, metastases, or death) compared with clinical group 1 (no recurrence or metastasis beyond a sentinel node) (P < .0001). Older age and greater tumor thickness were strongly associated with poorer outcome (P = .01). CONCLUSIONS: IMS diagnosis of ASN better predicted clinical outcome than histopathology. Diagnosis of Spitzoid melanoma by IMS was strongly associated with aggressive clinical behavior. IMS analysis using a proteomic signature may improve the diagnosis and prediction of outcome/risk stratification for patients with ASN. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of the American Academy of Dermatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject atypical Spitzoid neoplasm en_US
dc.subject histopathology en_US
dc.subject imaging mass spectrometry en_US
dc.subject mass spectrometry en_US
dc.subject Mass Spectrometry en_US
dc.subject Spitz nevus en_US
dc.subject Spitzoid melanoma en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Age Factors en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Diagnosis, Differential en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Lymphatic Metastasis en_US
dc.subject Male en_US
dc.subject Melanoma/chemistry/diagnostic imaging/secondary en_US
dc.subject Middle Aged en_US
dc.subject Neoplasm Recurrence, Local/chemistry/diagnostic imaging/pathology en_US
dc.subject Nevus, Epithelioid and Spindle Cell/chemistry/diagnostic imaging/pathology en_US
dc.subject Proteins/analysis en_US
dc.subject Retrospective Studies en_US
dc.subject Risk Assessment en_US
dc.subject Sentinel Lymph Node Biopsy en_US
dc.subject Skin Neoplasms/chemistry/diagnostic imaging/pathology en_US
dc.subject Treatment Outcome en_US
dc.subject Tumor Burden en_US
dc.subject Young Adult en_US
dc.title Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jaad.2016.07.007
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1097-6787


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