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Etiological Role and Repeated Infections of Sapovirus among Children Aged Less than 2 Years in a Cohort Study in a Peri-urban Community of Peru

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dc.contributor.author Liu, Xiaofang
dc.contributor.author Jahuira, Helena
dc.contributor.author Gilman, Robert H.
dc.contributor.author Alva, Alicia
dc.contributor.author Cabrera, Lilia
dc.contributor.author Okamoto, Michiko
dc.contributor.author Xu, Hang
dc.contributor.author Windle, Henry J.
dc.contributor.author Kelleher, Dermot
dc.contributor.author Varela, Marco
dc.contributor.author Verastegui, Manuela
dc.contributor.author Calderon, Maritza
dc.contributor.author Sanchez, Gerardo
dc.contributor.author Sarabia, Vanessa
dc.contributor.author Ballard, Sarah B.
dc.contributor.author Bern, Caryn
dc.contributor.author Mayta, Holger
dc.contributor.author Crabtree, Jean E.
dc.contributor.author Cama, Vitaliano
dc.contributor.author Saito, Mayuko
dc.contributor.author Oshitani, Hitoshi
dc.date.accessioned 2019-02-06T14:45:36Z
dc.date.available 2019-02-06T14:45:36Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5103
dc.description.abstract Human sapovirus has been shown to be one of the most important etiologies in pediatric patients with acute diarrhea. However, very limited data are available about the causative roles and epidemiology of sapovirus in community settings. A nested matched case-control study within a birth cohort study of acute diarrhea in a peri-urban community in Peru from 2007 to 2010 was conducted to investigate the attributable fraction (AF) and genetic diversity of sapovirus. By quantitative reverse transcription-real-time PCR (qPCR) sapovirus was detected in 12.4% (37/299) of diarrheal and 5.7% (17/300) of nondiarrheal stools (P = 0.004). The sapovirus AF (7.1%) was higher in the second year (13.2%) than in the first year (1.4%) of life of children. Ten known genotypes and one novel cluster (n = 5) within four genogroups (GI, GII, GIV, and GV) were identified by phylogenetic analysis of a partial VP1 gene. Further sequence analysis of the full VP1 gene revealed a possible novel genotype, tentatively named GII.8. Notably, symptomatic reinfections with different genotypes within the same (n = 3) or different (n = 5) genogroups were observed in eight children. Sapovirus exhibited a high attributable burden for acute gastroenteritis, especially in the second year of life, of children in a Peruvian community. Further large-scale studies are needed to understand better the global burden, genetic diversity, and repeated infections of sapovirus. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartof urn:issn:1098-660X
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Caliciviridae Infections/epidemiology/virology en_US
dc.subject Case-Control Studies en_US
dc.subject Cohort Studies en_US
dc.subject Diarrhea/epidemiology/virology en_US
dc.subject Female en_US
dc.subject Gastroenteritis/epidemiology/virology en_US
dc.subject Genotype en_US
dc.subject Humans en_US
dc.subject Infant en_US
dc.subject Infant, Newborn en_US
dc.subject Male en_US
dc.subject Peru/epidemiology en_US
dc.subject Phylogeny en_US
dc.subject Prevalence en_US
dc.subject Real-Time Polymerase Chain Reaction en_US
dc.subject Recurrence en_US
dc.subject Reverse Transcriptase Polymerase Chain Reaction en_US
dc.subject Sapovirus/classification/genetics/isolation & purification en_US
dc.subject Sequence Analysis, DNA en_US
dc.subject Suburban Population en_US
dc.title Etiological Role and Repeated Infections of Sapovirus among Children Aged Less than 2 Years in a Cohort Study in a Peri-urban Community of Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/JCM.03133-15
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01


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