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Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review

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dc.contributor.author Machicado Rivero, Claudia Inés Gloria
dc.contributor.author Machicado, Jorge-D.
dc.contributor.author Maco, Vicente
dc.contributor.author Terashima, Angelica
dc.contributor.author Marcos, Luis-A.
dc.date.accessioned 2019-02-06T14:45:37Z
dc.date.available 2019-02-06T14:45:37Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5109
dc.description.abstract BACKGROUND: Fascioliasis has been sporadically associated with chronic liver disease on previous studies. In order to describe the current evidence, we carried out a systematic review to assess the association between fascioliasis with liver fibrosis, cirrhosis and cancer. METHODOLOGY AND PRINCIPAL FINDINGS: A systematic search of electronic databases (PubMed, LILACS, Scopus, Embase, Cochrane, and Scielo) was conducted from June to July 2015 and yielded 1,557 published studies. Among 21 studies that met inclusion and exclusion criteria, 12 studies explored the association of F. hepatica with liver fibrosis, 4 with liver cirrhosis, and 5 with cancer. Globally these studies suggested the ability of F. hepatica to promote liver fibrosis and cirrhosis. The role of F. hepatica in cancer is unknown. Given the heterogeneity of the studies, a meta-analysis could not be performed. CONCLUSIONS: Future high-quality studies are needed to determine the role of F. hepatica on the development of liver fibrosis, liver cirrhosis, and cancer in humans. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Liver fibrosis en_US
dc.subject Cirrhosis en_US
dc.subject Fascioliasis en_US
dc.subject Hepatocellular carcinoma en_US
dc.subject Fasciola en_US
dc.subject Fibrosis en_US
dc.subject Parasitic diseases en_US
dc.subject Fasciola hepatica en_US
dc.title Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0004962
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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