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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

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dc.contributor.author Mallick, Swapan
dc.contributor.author Li, Heng
dc.contributor.author Lipson, Mark
dc.contributor.author Mathieson, Iain
dc.contributor.author Gymrek, Melissa
dc.contributor.author Racimo, Fernando
dc.contributor.author Zhao, Mengyao
dc.contributor.author Chennagiri, Niru
dc.contributor.author Nordenfelt, Susanne
dc.contributor.author Tandon, Arti
dc.contributor.author Skoglund, Pontus
dc.contributor.author Lazaridis, Iosif
dc.contributor.author Sankararaman, Sriram
dc.contributor.author Fu, Qiaomei
dc.contributor.author Rohland, Nadin
dc.contributor.author Renaud, Gabriel
dc.contributor.author Erlich, Yaniv
dc.contributor.author Willems, Thomas
dc.contributor.author Gallo, Carla
dc.contributor.author Spence, Jeffrey-P.
dc.contributor.author Song, Yun-S.
dc.contributor.author Poletti, Giovanni
dc.contributor.author Balloux, Francois
dc.contributor.author van-Driem, George
dc.contributor.author de-Knijff, Peter
dc.contributor.author Gallego Romero, Irene
dc.contributor.author Jha, Aashish-R.
dc.contributor.author Behar, Doron-M.
dc.contributor.author Bravi, Claudio-M.
dc.contributor.author Capelli, Cristian
dc.contributor.author Hervig, Tor
dc.contributor.author Moreno-Estrada, Andres
dc.contributor.author Posukh, Olga-L.
dc.contributor.author Balanovska, Elena
dc.contributor.author Balanovsky, Oleg
dc.contributor.author Karachanak-Yankova, Sena
dc.contributor.author Sahakyan, Hovhannes
dc.contributor.author Toncheva, Draga
dc.contributor.author Yepiskoposyan, Levon
dc.contributor.author Tyler-Smith, Chris
dc.contributor.author Xue, Yali
dc.contributor.author Abdullah, M. Syafiq
dc.contributor.author Ruiz-Linares, Andres
dc.contributor.author Beall, Cynthia-M.
dc.contributor.author Di-Rienzo, Anna
dc.contributor.author Jeong, Choongwon
dc.contributor.author Starikovskaya, Elena-B.
dc.contributor.author Metspalu, Ene
dc.contributor.author Parik, Juri
dc.contributor.author Villems, Richard
dc.contributor.author Henn, Brenna-M.
dc.contributor.author Hodoglugil, Ugur
dc.contributor.author Mahley, Robert
dc.contributor.author Sajantila, Antti
dc.contributor.author Stamatoyannopoulos, George
dc.contributor.author Wee, Joseph-T. S.
dc.contributor.author Khusainova, Rita
dc.contributor.author Khusnutdinova, Elza
dc.contributor.author Litvinov, Sergey
dc.contributor.author Ayodo, George
dc.contributor.author Comas, David
dc.contributor.author Hammer, Michael-F.
dc.contributor.author Kivisild, Toomas
dc.contributor.author Klitz, William
dc.contributor.author Winkler, Cheryl-A.
dc.contributor.author Labuda, Damian
dc.contributor.author Bamshad, Michael
dc.contributor.author Jorde, Lynn-B.
dc.contributor.author Tishkoff, Sarah-A.
dc.contributor.author Watkins, W. Scott
dc.contributor.author Metspalu, Mait
dc.contributor.author Dryomov, Stanislav
dc.contributor.author Sukernik, Rem
dc.contributor.author Singh, Lalji
dc.contributor.author Thangaraj, Kumarasamy
dc.contributor.author Paabo, Svante
dc.contributor.author Kelso, Janet
dc.contributor.author Patterson, Nick
dc.contributor.author Reich, David
dc.date.accessioned 2019-02-06T14:45:37Z
dc.date.available 2019-02-06T14:45:37Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5114
dc.description.abstract Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1476-4687
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genomics en_US
dc.subject Mutation Rate en_US
dc.subject Phylogeny en_US
dc.subject African Continental Ancestry Group/genetics en_US
dc.subject Animals en_US
dc.subject Australia en_US
dc.subject Continental Population Groups/genetics en_US
dc.subject Datasets as Topic en_US
dc.subject Genetic Variation/genetics en_US
dc.subject Genetics, Population en_US
dc.subject Genome, Human/genetics en_US
dc.subject History, Ancient en_US
dc.subject Human Migration/history en_US
dc.subject Humans en_US
dc.subject Neanderthals/genetics en_US
dc.subject New Guinea en_US
dc.subject Oceanic Ancestry Group/genetics en_US
dc.subject Sequence Analysis, DNA en_US
dc.subject Species Specificity en_US
dc.subject Time Factors en_US
dc.title The Simons Genome Diversity Project: 300 genomes from 142 diverse populations en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/nature18964
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.02

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