Universidad Peruana Cayetano Heredia

High Prevalence of Asymptomatic Neurocysticercosis in an Endemic Rural Community in Peru

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dc.contributor.author Moyano, Luz M.
dc.contributor.author O'Neal, Seth E.
dc.contributor.author Ayvar, Viterbo
dc.contributor.author Gonzalvez, Guillermo
dc.contributor.author Gamboa Morán, Ricardo
dc.contributor.author Vilchez Barreto, Percy Mcquen
dc.contributor.author Rodriguez, Silvia
dc.contributor.author Reistetter, Joe
dc.contributor.author Tsang, Victor C. W.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-02-06T14:45:56Z
dc.date.available 2019-02-06T14:45:56Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5126
dc.description.abstract BACKGROUND: Neurocysticercosis is a common helminthic infection of the central nervous system and an important cause of adult-onset epilepsy in endemic countries. However, few studies have examined associations between neurologic symptoms, serology and radiographic findings on a community-level. METHODOLOGY: We conducted a population-based study of resident's >/=2 years old in a highly endemic village in Peru (pop. 454). We applied a 14 -question neurologic screening tool and evaluated serum for antibodies against Taenia solium cysticercosis using enzyme-linked immunoelectrotransfer blot (LLGP-EITB). We invited all residents >/=18 years old to have non-contrast computerized tomography (CT) of the head. PRINCIPAL FINDINGS: Of the 385 residents who provided serum samples, 142 (36.9%) were seropositive. Of the 256 residents who underwent CT scan, 48 (18.8%) had brain calcifications consistent with NCC; 8/48 (17.0%) reported a history of headache and/or seizures. Exposure to T. solium is very common in this endemic community where 1 out of 5 residents had brain calcifications. However, the vast majority of people with calcifications were asymptomatic. CONCLUSION: This study reports a high prevalence of NCC infection in an endemic community in Peru and confirms that a large proportion of apparently asymptomatic residents have brain calcifications that could provoke seizures in the future. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Endemic Diseases en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Animals en_US
dc.subject Antibodies, Helminth/blood en_US
dc.subject Asymptomatic Infections/epidemiology en_US
dc.subject Brain/parasitology/pathology en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Mass Screening en_US
dc.subject Middle Aged en_US
dc.subject Neurocysticercosis/blood/diagnostic imaging/epidemiology/immunology en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Rural Health en_US
dc.subject Seizures/epidemiology/etiology/parasitology en_US
dc.subject Taenia solium/immunology/isolation & purification en_US
dc.subject Tomography, X-Ray Computed en_US
dc.subject Young Adult en_US
dc.title High Prevalence of Asymptomatic Neurocysticercosis in an Endemic Rural Community in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0005130
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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