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A prospective longitudinal study of tuberculosis among household contacts of smear-positive tuberculosis cases in Lima, Peru

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dc.contributor.author Otero, Larissa
dc.contributor.author Shah, Lena
dc.contributor.author Verdonck, Kristien
dc.contributor.author Battaglioli, Tullia
dc.contributor.author Brewer, Timothy
dc.contributor.author Gotuzzo, Eduardo
dc.contributor.author Seas, Carlos
dc.contributor.author Van-der-Stuyft, Patrick
dc.date.accessioned 2019-02-06T14:45:56Z
dc.date.available 2019-02-06T14:45:56Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5130
dc.description.abstract BACKGROUND: Household contacts (HHCs) of TB cases are at increased risk for TB disease compared to the general population but the risk may be modified by individual or household factors. We conducted a study to determine incident TB among HHCs over two years after exposure and to identify individual and household level risk factors. METHODS: Adults newly diagnosed with a first episode of smear-positive pulmonary TB (index cases) between March 2010 and December 2011 in eastern Lima, were interviewed to identify their HHC and household characteristics. TB registers were reviewed for up to two years after the index case diagnosis and house visits were made to ascertain TB cases among HHC. The TB incidence rate ratio among HHCs as a function of risk factors was determined using generalized linear mixed models. RESULTS: The 1178 index cases reported 5466 HHCs. In 402/1178 (34.1 %) households, at least one HHC had experienced a TB episode ever. The TB incidence among HHCs was 1918 (95%CI 1669-2194) per 100,000 person-years overall, and was 2392 (95%CI 2005-2833) and 1435 (95%CI 1139-1787) per 100,000 person-years in the first and second year, respectively. Incident TB occurred more than six months following the index case's TB diagnosis in 121/205 (59.0 %) HHCs. In HHCs, bacillary load and time between symptoms and treatment initiation in the index case, as well as the relationship to the index case and the sex of the HHC all had a significant association with TB incidence in HHCs. CONCLUSIONS: Incidence of TB among HHCs was more than ten times higher than in the general population. Certain HHC and households were at higher risk of TB, we recommend studies to compare HHC investigation to households at highest risk versus current practice, in terms of efficiency. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof urn:issn:1471-2334
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Contact Tracing en_US
dc.subject Family Characteristics en_US
dc.subject Household contact investigation en_US
dc.subject Longitudinal study en_US
dc.subject Multilevel analysis en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Child en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Incidence en_US
dc.subject Linear Models en_US
dc.subject Longitudinal Studies en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Mycobacterium tuberculosis/isolation & purification en_US
dc.subject Peru/epidemiology en_US
dc.subject Prospective Studies en_US
dc.subject Risk Factors en_US
dc.subject Sputum/microbiology en_US
dc.subject Tuberculosis, Pulmonary/diagnosis/epidemiology/transmission en_US
dc.subject Young Adult en_US
dc.title A prospective longitudinal study of tuberculosis among household contacts of smear-positive tuberculosis cases in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12879-016-1616-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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