dc.contributor.author |
Palma, Noemi |
|
dc.contributor.author |
Gomes, Claudia |
|
dc.contributor.author |
Riveros Ramirez, Maribel Denise |
|
dc.contributor.author |
Garcia, Wilfredo |
|
dc.contributor.author |
Martinez-Puchol, Sandra |
|
dc.contributor.author |
Ruiz-Roldan, Lidia |
|
dc.contributor.author |
Mateu, Judit |
|
dc.contributor.author |
García Apac, Coralith Marlinda |
|
dc.contributor.author |
Jacobs, Jan |
|
dc.contributor.author |
Ochoa Woodell, Theresa Jean |
|
dc.contributor.author |
Ruiz, Joaquim |
|
dc.date.accessioned |
2019-02-06T14:45:57Z |
|
dc.date.available |
2019-02-06T14:45:57Z |
|
dc.date.issued |
2016 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/5134 |
|
dc.description.abstract |
The presence of 25 virulence genes (VGs), genetic phylogroups, quinolone-resistance and Extended Spectrum beta-lactamase (ESBL)-production was assessed in 65 Escherichia coli isolates from blood cultures in children <5 years in Peru. The most frequent VGs were fimA (89.2%), iutA (83.1%), agn43 (72.3%), iucA (67.7%), and fyuA (49.2%). The isolates belonged to D (47.7%), A (26.1%), B1 (21.5%), and B2 (4.6%) phylogroups. D + B2 isolates presented a high number of fimA, hly, papC, sat, and fyuA genes. Quinolone-susceptible (22 isolates - 33.8%) and ESBL-negative (31 isolates - 47.7%) isolates carried more VGs that their respective counterparts (5.7 vs. 4.7 and 5.3 vs. 4.4 respectively); the frequency of the fyuA, aat, aap, and hly genes significantly differed between quinolone-resistant and quinolone-susceptible isolates. Neonatal sepsis isolates tended to be more quinolone-resistant (P = 0.0697) and ESBL-producers (P = 0.0776). Early-onset neonatal sepsis isolates possessed a high number of VGs (5.2 VGs), especially in neonates of </=1 day (5.9 VGs). |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Diagnostic Microbiology and Infectious Disease |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Anti-Bacterial Agents/pharmacology |
en_US |
dc.subject |
Bacteremia |
en_US |
dc.subject |
Bacteremia/microbiology |
en_US |
dc.subject |
beta-Lactamases/metabolism |
en_US |
dc.subject |
Blood/microbiology |
en_US |
dc.subject |
Child, Preschool |
en_US |
dc.subject |
Drug Resistance, Bacterial |
en_US |
dc.subject |
ESBL |
en_US |
dc.subject |
Escherichia coli Infections/microbiology |
en_US |
dc.subject |
Escherichia coli/classification/enzymology/isolation & purification/pathogenicity |
en_US |
dc.subject |
Extra-intestinal Escherichia coli |
en_US |
dc.subject |
Female |
en_US |
dc.subject |
Genotype |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Infant |
en_US |
dc.subject |
Infant, Newborn |
en_US |
dc.subject |
Male |
en_US |
dc.subject |
Neonatal sepsis |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
Quinolone-resistance |
en_US |
dc.subject |
Quinolones/pharmacology |
en_US |
dc.subject |
Virulence |
en_US |
dc.subject |
Virulence Factors/analysis/genetics |
en_US |
dc.title |
Virulence factors profiles and ESBL production in Escherichia coli causing bacteremia in Peruvian children |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.diagmicrobio.2016.05.017 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.03.08 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#1.06.01 |
|
dc.relation.issn |
1879-0070 |
|