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Virulence factors profiles and ESBL production in Escherichia coli causing bacteremia in Peruvian children

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dc.contributor.author Palma, Noemi
dc.contributor.author Gomes, Claudia
dc.contributor.author Riveros, Maribel
dc.contributor.author Garcia, Wilfredo
dc.contributor.author Martinez-Puchol, Sandra
dc.contributor.author Ruiz-Roldan, Lidia
dc.contributor.author Mateu, Judit
dc.contributor.author Garcia, Coralith
dc.contributor.author Jacobs, Jan
dc.contributor.author Ochoa, Theresa-J.
dc.contributor.author Ruiz, Joaquim
dc.date.accessioned 2019-02-06T14:45:57Z
dc.date.available 2019-02-06T14:45:57Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5134
dc.description.abstract The presence of 25 virulence genes (VGs), genetic phylogroups, quinolone-resistance and Extended Spectrum beta-lactamase (ESBL)-production was assessed in 65 Escherichia coli isolates from blood cultures in children <5 years in Peru. The most frequent VGs were fimA (89.2%), iutA (83.1%), agn43 (72.3%), iucA (67.7%), and fyuA (49.2%). The isolates belonged to D (47.7%), A (26.1%), B1 (21.5%), and B2 (4.6%) phylogroups. D + B2 isolates presented a high number of fimA, hly, papC, sat, and fyuA genes. Quinolone-susceptible (22 isolates - 33.8%) and ESBL-negative (31 isolates - 47.7%) isolates carried more VGs that their respective counterparts (5.7 vs. 4.7 and 5.3 vs. 4.4 respectively); the frequency of the fyuA, aat, aap, and hly genes significantly differed between quinolone-resistant and quinolone-susceptible isolates. Neonatal sepsis isolates tended to be more quinolone-resistant (P = 0.0697) and ESBL-producers (P = 0.0776). Early-onset neonatal sepsis isolates possessed a high number of VGs (5.2 VGs), especially in neonates of </=1 day (5.9 VGs). en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1879-0070
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Anti-Bacterial Agents/pharmacology en_US
dc.subject Bacteremia en_US
dc.subject Bacteremia/microbiology en_US
dc.subject beta-Lactamases/metabolism en_US
dc.subject Blood/microbiology en_US
dc.subject Child, Preschool en_US
dc.subject Drug Resistance, Bacterial en_US
dc.subject ESBL en_US
dc.subject Escherichia coli Infections/microbiology en_US
dc.subject Escherichia coli/classification/enzymology/isolation & purification/pathogenicity en_US
dc.subject Extra-intestinal Escherichia coli en_US
dc.subject Female en_US
dc.subject Genotype en_US
dc.subject Humans en_US
dc.subject Infant en_US
dc.subject Infant, Newborn en_US
dc.subject Male en_US
dc.subject Neonatal sepsis en_US
dc.subject Peru en_US
dc.subject Quinolone-resistance en_US
dc.subject Quinolones/pharmacology en_US
dc.subject Virulence en_US
dc.subject Virulence Factors/analysis/genetics en_US
dc.title Virulence factors profiles and ESBL production in Escherichia coli causing bacteremia in Peruvian children en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.diagmicrobio.2016.05.017
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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