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dc.contributor.author | Palma, Noemi | |
dc.contributor.author | Gomes, Claudia | |
dc.contributor.author | Riveros Ramirez, Maribel Denise | |
dc.contributor.author | Garcia, Wilfredo | |
dc.contributor.author | Martinez-Puchol, Sandra | |
dc.contributor.author | Ruiz-Roldan, Lidia | |
dc.contributor.author | Mateu, Judit | |
dc.contributor.author | García Apac, Coralith Marlinda | |
dc.contributor.author | Jacobs, Jan | |
dc.contributor.author | Ochoa Woodell, Theresa Jean | |
dc.contributor.author | Ruiz, Joaquim | |
dc.date.accessioned | 2019-02-06T14:45:57Z | |
dc.date.available | 2019-02-06T14:45:57Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/5134 | |
dc.description.abstract | The presence of 25 virulence genes (VGs), genetic phylogroups, quinolone-resistance and Extended Spectrum beta-lactamase (ESBL)-production was assessed in 65 Escherichia coli isolates from blood cultures in children <5 years in Peru. The most frequent VGs were fimA (89.2%), iutA (83.1%), agn43 (72.3%), iucA (67.7%), and fyuA (49.2%). The isolates belonged to D (47.7%), A (26.1%), B1 (21.5%), and B2 (4.6%) phylogroups. D + B2 isolates presented a high number of fimA, hly, papC, sat, and fyuA genes. Quinolone-susceptible (22 isolates - 33.8%) and ESBL-negative (31 isolates - 47.7%) isolates carried more VGs that their respective counterparts (5.7 vs. 4.7 and 5.3 vs. 4.4 respectively); the frequency of the fyuA, aat, aap, and hly genes significantly differed between quinolone-resistant and quinolone-susceptible isolates. Neonatal sepsis isolates tended to be more quinolone-resistant (P = 0.0697) and ESBL-producers (P = 0.0776). Early-onset neonatal sepsis isolates possessed a high number of VGs (5.2 VGs), especially in neonates of </=1 day (5.9 VGs). | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Diagnostic Microbiology and Infectious Disease | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Anti-Bacterial Agents/pharmacology | en_US |
dc.subject | Bacteremia | en_US |
dc.subject | Bacteremia/microbiology | en_US |
dc.subject | beta-Lactamases/metabolism | en_US |
dc.subject | Blood/microbiology | en_US |
dc.subject | Child, Preschool | en_US |
dc.subject | Drug Resistance, Bacterial | en_US |
dc.subject | ESBL | en_US |
dc.subject | Escherichia coli Infections/microbiology | en_US |
dc.subject | Escherichia coli/classification/enzymology/isolation & purification/pathogenicity | en_US |
dc.subject | Extra-intestinal Escherichia coli | en_US |
dc.subject | Female | en_US |
dc.subject | Genotype | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant | en_US |
dc.subject | Infant, Newborn | en_US |
dc.subject | Male | en_US |
dc.subject | Neonatal sepsis | en_US |
dc.subject | Peru | en_US |
dc.subject | Quinolone-resistance | en_US |
dc.subject | Quinolones/pharmacology | en_US |
dc.subject | Virulence | en_US |
dc.subject | Virulence Factors/analysis/genetics | en_US |
dc.title | Virulence factors profiles and ESBL production in Escherichia coli causing bacteremia in Peruvian children | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.diagmicrobio.2016.05.017 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.06.01 | |
dc.relation.issn | 1879-0070 |
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