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Interconnected microbiomes and resistomes in low-income human habitats

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dc.contributor.author Pehrsson, Erica C.
dc.contributor.author Tsukayama, Pablo
dc.contributor.author Patel, Sanket
dc.contributor.author Mejia-Bautista, Melissa
dc.contributor.author Sosa-Soto, Giordano
dc.contributor.author Navarrete, Karla M.
dc.contributor.author Calderon, Maritza
dc.contributor.author Cabrera, Lilia
dc.contributor.author Hoyos-Arango, William
dc.contributor.author Bertoli, M. Teresita
dc.contributor.author Berg, Douglas E.
dc.contributor.author Gilman, Robert H.
dc.contributor.author Dantas, Gautam
dc.date.accessioned 2019-02-06T14:45:57Z
dc.date.available 2019-02-06T14:45:57Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5141
dc.description.abstract Antibiotic-resistant infections annually claim hundreds of thousands of lives worldwide. This problem is exacerbated by exchange of resistance genes between pathogens and benign microbes from diverse habitats. Mapping resistance gene dissemination between humans and their environment is a public health priority. Here we characterized the bacterial community structure and resistance exchange networks of hundreds of interconnected human faecal and environmental samples from two low-income Latin American communities. We found that resistomes across habitats are generally structured by bacterial phylogeny along ecological gradients, but identified key resistance genes that cross habitat boundaries and determined their association with mobile genetic elements. We also assessed the effectiveness of widely used excreta management strategies in reducing faecal bacteria and resistance genes in these settings representative of low- and middle-income countries. Our results lay the foundation for quantitative risk assessment and surveillance of resistance gene dissemination across interconnected habitats in settings representing over two-thirds of the world's population. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1476-4687
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Ecosystem en_US
dc.subject Gene Transfer, Horizontal en_US
dc.subject Agriculture en_US
dc.subject Bacteria/classification/genetics en_US
dc.subject Developing Countries/economics en_US
dc.subject Drug Resistance, Microbial/genetics en_US
dc.subject El Salvador en_US
dc.subject Environmental Monitoring en_US
dc.subject Feces/microbiology en_US
dc.subject Humans en_US
dc.subject Metagenomics en_US
dc.subject Microbiota/genetics en_US
dc.subject Molecular Epidemiology en_US
dc.subject Peru en_US
dc.subject Phylogeny en_US
dc.subject Residence Characteristics en_US
dc.subject Risk Assessment en_US
dc.subject Sewage/microbiology en_US
dc.subject Socioeconomic Factors en_US
dc.title Interconnected microbiomes and resistomes in low-income human habitats en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/nature17672
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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