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Calling in sick: impacts of fever on intra-urban human mobility

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dc.contributor.author Perkins, T. Alex
dc.contributor.author Paz-Soldan Parlette, Valerie Andrea
dc.contributor.author Stoddard, Steven-T.
dc.contributor.author Morrison, Amy-C.
dc.contributor.author Forshey, Brett-M.
dc.contributor.author Long, Kanya-C.
dc.contributor.author Halsey, Eric-S.
dc.contributor.author Kochel, Tadeusz-J.
dc.contributor.author Elder, John-P.
dc.contributor.author Kitron, Uriel
dc.contributor.author Scott, Thomas-W.
dc.contributor.author Vazquez-Prokopec, Gonzalo-M.
dc.date.accessioned 2019-02-06T14:45:57Z
dc.date.available 2019-02-06T14:45:57Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5142
dc.description.abstract Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two groups of febrile individuals (dengue-positive and dengue-negative) with an afebrile control group. A retrospective, semi-structured interview allowed us to quantify multiple aspects of mobility during the two-week period preceding each interview. We fitted nested models of each aspect of mobility to data from interviews and compared models using likelihood ratio tests to determine whether there were statistically distinguishable differences in mobility attributable to fever or its aetiology. Compared with afebrile individuals, febrile study participants spent more time at home, visited fewer locations, and, in some cases, visited locations closer to home and spent less time at certain types of locations. These multifaceted impacts are consistent with the possibility that disease-mediated changes in host mobility generate dynamic and complex changes in host contact network structure. en_US
dc.language.iso eng
dc.publisher Royal Society Publishing
dc.relation.ispartofseries Proceedings - Royal Society. Biological Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject activity space en_US
dc.subject contact en_US
dc.subject dengue en_US
dc.subject infection en_US
dc.subject movement en_US
dc.subject network en_US
dc.subject Travel en_US
dc.subject Case-Control Studies en_US
dc.subject Cities en_US
dc.subject Dengue/epidemiology en_US
dc.subject Fever/epidemiology en_US
dc.subject Humans en_US
dc.subject Likelihood Functions en_US
dc.subject Models, Theoretical en_US
dc.subject Peru/epidemiology en_US
dc.subject Retrospective Studies en_US
dc.title Calling in sick: impacts of fever on intra-urban human mobility en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1098/rspb.2016.0390
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.00
dc.relation.issn 1471-2954


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