Universidad Peruana Cayetano Heredia

Manual MGIT system for the detection of Mycobacterium tuberculosis: insights from a high TB burden setting

Mostrar el registro sencillo del ítem

dc.contributor.author Quispe, R.
dc.contributor.author Valle, G. A.
dc.contributor.author Huapaya, J. A.
dc.contributor.author Novoa, I.
dc.contributor.author Giraldo, J.
dc.contributor.author Cáceres Nakiche, Tatiana
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Zamudio Fuertes, Carlos Eduardo
dc.contributor.author Seas Ramos, Carlos Rafael
dc.date.accessioned 2019-02-06T14:45:58Z
dc.date.available 2019-02-06T14:45:58Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5148
dc.description.abstract OBJECTIVE: To evaluate the diagnostic performance of manual MGIT (MMGIT) compared to the gold standard, Lowenstein-Jensen (LJ), in the diagnosis of pulmonary tuberculosis (TB) in a high-burden setting. METHODS: Individuals with suspected TB enrolled in parallel diagnostic trials during 2007-2011 were included. Two samples were obtained from each patient and inoculated into MMGIT and LJ medium. Diagnostic tests were performed, and the incremental yield of a second test and time to detection (TTD) were calculated. Analyses were performed per patient and per sample. Gold standard was based on LJ culture. RESULTS: In the per patient and per sample analysis, we evaluated 1436 patients and 4142 samples. The sensitivity and specificity for smear and MMGIT per sample were respectively 89.9%/92.2% and 97.1%/98.9%. Contamination was observed in 1.4% of samples on MMGIT. The mean TTD (days) was 11.8 for MMGIT and 22.9 for LJ. The sensitivity and specificity for smear and MMGIT per patient were respectively 89.9% and 92.2% and 97.1% and 98.3%. A second MMGIT culture had an incremental yield of 1.6%. CONCLUSIONS: MMGIT has high sensitivity and specificity, regardless of smear result, with a 50% reduction in TTD compared to LJ. These features make MMGIT an acceptable TB diagnostic method for use in resource-limited settings. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartofseries International Journal of Tuberculosis and Lung Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Bacteriological Techniques/economics en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Female en_US
dc.subject Health Care Costs en_US
dc.subject Humans en_US
dc.subject Lung/microbiology en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Mycobacterium tuberculosis/isolation & purification en_US
dc.subject Peru/epidemiology en_US
dc.subject Predictive Value of Tests en_US
dc.subject Reproducibility of Results en_US
dc.subject Sputum/microbiology en_US
dc.subject Time Factors en_US
dc.subject Tuberculosis, Pulmonary/diagnosis/economics/epidemiology/microbiology en_US
dc.subject Young Adult en_US
dc.title Manual MGIT system for the detection of Mycobacterium tuberculosis: insights from a high TB burden setting en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.15.0489
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1815-7920


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas