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Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA(2) Dichotomy across Micrurus Venoms

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dc.contributor.author Sanz, Libia
dc.contributor.author Pla, Davinia
dc.contributor.author Perez, Alicia
dc.contributor.author Rodriguez, Yania
dc.contributor.author Zavaleta Martinez-Vargas, Alfonso
dc.contributor.author Salas, Maria
dc.contributor.author Lomonte, Bruno
dc.contributor.author Calvete, Juan-J.
dc.date.accessioned 2019-02-06T14:45:58Z
dc.date.available 2019-02-06T14:45:58Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5158
dc.description.abstract The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified >/=38 proteins belonging to only four snake venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms (~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert coral snake venom. Phospholipases A(2) (PLA(2)s; seven isoforms, 4.1% of the venom proteome), 1-3 Kunitz-type proteins (1.6%), and 1-2 l-amino acid oxidases (LAO, 0.7%) complete the toxin arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent venom phenotypes, i.e., 3FTx- and PLA(2)-predominant venom proteomes, may constitute a general trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA(2) dichotomy may be widely distributed among Elapidae venoms. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Toxins
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Elapidae en_US
dc.subject mass spectrometry en_US
dc.subject Micrurus tschudii tschudii venom en_US
dc.subject snake venom phospholipase A2 en_US
dc.subject snake venom proteome en_US
dc.subject three-finger toxin en_US
dc.subject venomics en_US
dc.subject Animals en_US
dc.subject Chromatography, High Pressure Liquid en_US
dc.subject Elapid Venoms/chemistry/toxicity en_US
dc.subject Electrophoresis, Polyacrylamide Gel en_US
dc.subject Female en_US
dc.subject Lethal Dose 50 en_US
dc.subject Male en_US
dc.subject Mice, Inbred Strains en_US
dc.subject Phospholipases A2/chemistry/toxicity en_US
dc.subject Proteome/chemistry/toxicity en_US
dc.subject Species Specificity en_US
dc.subject Toxins, Biological/chemistry/toxicity en_US
dc.title Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA(2) Dichotomy across Micrurus Venoms en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/toxins8060178
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.relation.issn 2072-6651


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