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Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study

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dc.contributor.author Seyoum, Dinberu
dc.contributor.author Kifle, Yehenew-Getachew
dc.contributor.author Rondeau, Virginie
dc.contributor.author Yewhalaw, Delenasaw
dc.contributor.author Duchateau, Luc
dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Speybroeck, Niko
dc.date.accessioned 2019-02-06T14:45:59Z
dc.date.available 2019-02-06T14:45:59Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5161
dc.description.abstract BACKGROUND: The identification of epidemiological pattern of infection with Plasmodium falciparum and Plasmodium vivax in malaria-endemic area, where multiple episodes are common, is important for intervention programmes. METHODS: A longitudinal cohort study based on weekly house-to-house visits was conducted between July 2008 and June 2010 in 2040 children less than 10 years of age, living nearby the Gilgel-Gibe hydroelectric power dam reservoir in order to determine factors associated with increased P. vivax and P. falciparum incidence. Two types of multivariate frailty models were applied (using time-to-first malaria episode data and time-to-recurrent malaria episode data), allowing the estimation of adjusted hazard ratios (AHR) of potential risk factors (gender, age, proximity to the dam reservoir, and season) for species-specific malaria incidence. RESULTS: Of 2040 children in 96 weeks of follow up, 864 children experienced at least one malaria episode: 685 due to P. falciparum in 548 children, and 385 due to P. vivax in 316 children. Plasmodium vivax and P. falciparum malaria incidence rates were 8.2 (95 % CI: 7.3-9.1) and 14.6 (95 % CI: 13.4-15.6) per 1000 children per month, respectively. According to the time-to-recurrent event models, children aged >/=7 years had a lower risk of presenting P. vivax episodes (AHR = 0.6; 95 % CI: 0.4-0.9), but a higher risk of P. falciparum episodes, when compared with children under </=3 years (AHR = 1.2; 95 % CI: 1.1-1.6). In addition, P. vivax (AHR = 2.7; 95 % CI: 2.2-3.5) and P. falciparum (AHR = 16.9; 95 % CI: 14.3-20.2) episodes were respectively 2.7 and 16.9 times more frequent in the dry season than in the long rainy season. CONCLUSIONS: The analysis of all malaria episodes (first and recurrent episodes) in the malaria cohort suggests different species-specific patterns of malaria disease in children, with mild seasonality in the incidence of P. vivax episodes mostly observed in younger age groups, and with marked seasonality in the incidence of P. falciparum episodes mainly seen in older children. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof urn:issn:1475-2875
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Cohort Studies en_US
dc.subject Ethiopia en_US
dc.subject Ethiopia/epidemiology en_US
dc.subject Female en_US
dc.subject Frailty model en_US
dc.subject Humans en_US
dc.subject Incidence en_US
dc.subject Infant en_US
dc.subject Infant, Newborn en_US
dc.subject Longitudinal Studies en_US
dc.subject Malaria, Falciparum/epidemiology/parasitology en_US
dc.subject Malaria, Vivax/epidemiology/parasitology en_US
dc.subject Male en_US
dc.subject Models, Theoretical en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium falciparum/physiology en_US
dc.subject Plasmodium vivax en_US
dc.subject Plasmodium vivax/physiology en_US
dc.subject Prospective Studies en_US
dc.subject Recurrent malaria en_US
dc.subject Risk Factors en_US
dc.title Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12936-016-1253-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08

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