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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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dc.contributor.author Stucki, David
dc.contributor.author Brites, Daniela
dc.contributor.author Jeljeli, Leila
dc.contributor.author Coscolla, Mireia
dc.contributor.author Liu, Qingyun
dc.contributor.author Trauner, Andrej
dc.contributor.author Fenner, Lukas
dc.contributor.author Rutaihwa, Liliana
dc.contributor.author Borrell, Sonia
dc.contributor.author Luo, Tao
dc.contributor.author Gao, Qian
dc.contributor.author Kato-Maeda, Midori
dc.contributor.author Ballif, Marie
dc.contributor.author Egger, Matthias
dc.contributor.author Macedo, Rita
dc.contributor.author Mardassi, Helmi
dc.contributor.author Moreno, Milagros
dc.contributor.author Tudo-Vilanova, Griselda
dc.contributor.author Fyfe, Janet
dc.contributor.author Globan, Maria
dc.contributor.author Thomas, Jackson
dc.contributor.author Jamieson, Frances
dc.contributor.author Guthrie, Jennifer-L.
dc.contributor.author Asante-Poku, Adwoa
dc.contributor.author Yeboah-Manu, Dorothy
dc.contributor.author Wampande, Eddie
dc.contributor.author Ssengooba, Willy
dc.contributor.author Joloba, Moses
dc.contributor.author Henry-Boom, W.
dc.contributor.author Basu, Indira
dc.contributor.author Bower, James
dc.contributor.author Saraiva, Margarida
dc.contributor.author Vaconcellos, Sidra-E. G.
dc.contributor.author Suffys, Philip
dc.contributor.author Koch, Anastasia
dc.contributor.author Wilkinson, Robert
dc.contributor.author Gail-Bekker, Linda
dc.contributor.author Malla, Bijaya
dc.contributor.author Ley, Serej-D.
dc.contributor.author Beck, Hans-Peter
dc.contributor.author de-Jong, Bouke-C.
dc.contributor.author Toit, Kadri
dc.contributor.author Sanchez-Padilla, Elisabeth
dc.contributor.author Bonnet, Maryline
dc.contributor.author Gil-Brusola, Ana
dc.contributor.author Frank, Matthias
dc.contributor.author Penlap-Beng, Veronique-N.
dc.contributor.author Eisenach, Kathleen
dc.contributor.author Alani, Issam
dc.contributor.author Wangui-Ndung'u, Perpetual
dc.contributor.author Revathi, Gunturu
dc.contributor.author Gehre, Florian
dc.contributor.author Akter, Suriya
dc.contributor.author Ntoumi, Francine
dc.contributor.author Stewart-Isherwood, Lynsey
dc.contributor.author Ntinginya, Nyanda-E.
dc.contributor.author Rachow, Andrea
dc.contributor.author Hoelscher, Michael
dc.contributor.author Cirillo, Daniela-Maria
dc.contributor.author Skenders, Girts
dc.contributor.author Hoffner, Sven
dc.contributor.author Bakonyte, Daiva
dc.contributor.author Stakenas, Petras
dc.contributor.author Diel, Roland
dc.contributor.author Crudu, Valeriu
dc.contributor.author Moldovan, Olga
dc.contributor.author Al-Hajoj, Sahal
dc.contributor.author Otero Vegas, Larissa
dc.contributor.author Barletta, Francesca
dc.contributor.author Jane-Carter, E.
dc.contributor.author Diero, Lameck
dc.contributor.author Supply, Philip
dc.contributor.author Comas, Inaki
dc.contributor.author Niemann, Stefan
dc.contributor.author Gagneux, Sebastien
dc.date.accessioned 2019-02-06T14:48:07Z
dc.date.available 2019-02-06T14:48:07Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5166
dc.description.abstract Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Nature Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject DNA, Bacterial/analysis en_US
dc.subject Genomics/methods en_US
dc.subject Genotype en_US
dc.subject Global Health en_US
dc.subject Humans en_US
dc.subject Mycobacterium tuberculosis/classification/genetics/isolation & purification en_US
dc.subject Phylogeography en_US
dc.subject Polymorphism, Genetic/genetics en_US
dc.subject Tuberculosis/genetics/microbiology en_US
dc.title Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/ng.3704
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.relation.issn 1546-1718


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