Universidad Peruana Cayetano Heredia

Impact of Infection Control Measures to Control an Outbreak of Multidrug-Resistant Tuberculosis in a Human Immunodeficiency Virus Ward, Peru

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dc.contributor.author Ticona, Eduardo
dc.contributor.author Huaroto, Luz
dc.contributor.author Kirwan, Daniela E.
dc.contributor.author Chumpitaz, Milagros
dc.contributor.author Munayco, Cesar V.
dc.contributor.author Maguina, Monica
dc.contributor.author Tovar, Marco A.
dc.contributor.author Evans, Carlton Anthony William
dc.contributor.author Escombe, Roderick
dc.contributor.author Gilman, Robert Hugh
dc.date.accessioned 2019-02-06T14:48:07Z
dc.date.available 2019-02-06T14:48:07Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5169
dc.description.abstract Multidrug-resistant tuberculosis (MDRTB) rates in a human immunodeficiency virus (HIV) care facility increased by the year 2000-56% of TB cases, eight times the national MDRTB rate. We reported the effect of tuberculosis infection control measures that were introduced in 2001 and that consisted of 1) building a respiratory isolation ward with mechanical ventilation, 2) triage segregation of patients, 3) relocation of waiting room to outdoors, 4) rapid sputum smear microscopy, and 5) culture/drug-susceptibility testing with the microscopic-observation drug-susceptibility assay. Records pertaining to patients attending the study site between 1997 and 2004 were reviewed. Six hundred and fifty five HIV/TB-coinfected patients (mean age 33 years, 79% male) who attended the service during the study period were included. After the intervention, MDRTB rates declined to 20% of TB cases by the year 2004 (P = 0.01). Extremely limited access to antiretroviral therapy and specific MDRTB therapy did not change during this period, and concurrently, national MDRTB prevalence increased, implying that the infection control measures caused the fall in MDRTB rates. The infection control measures were estimated to have cost US$91,031 while preventing 97 MDRTB cases, potentially saving US$1,430,026. Thus, this intervention significantly reduced MDRTB within an HIV care facility in this resource-constrained setting and should be cost-effective. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug Resistance, Multiple, Bacterial en_US
dc.subject Antitubercular Agents/therapeutic use en_US
dc.subject Costs and Cost Analysis en_US
dc.subject HIV Infections/complications/epidemiology en_US
dc.subject Hospital Costs en_US
dc.subject Humans en_US
dc.subject Infection Control/economics/methods en_US
dc.subject Patient Isolation en_US
dc.subject Peru/epidemiology en_US
dc.subject Retrospective Studies en_US
dc.subject Tuberculosis, Multidrug-Resistant/epidemiology/prevention & control en_US
dc.title Impact of Infection Control Measures to Control an Outbreak of Multidrug-Resistant Tuberculosis in a Human Immunodeficiency Virus Ward, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.15-0712
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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