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Plasma soluble erythropoietin receptor is decreased during sleep in Andean highlanders with Chronic Mountain Sickness

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dc.contributor.author Villafuerte, Francisco-C.
dc.contributor.author Corante, Noemi
dc.contributor.author Anza-Ramirez, Cecilia
dc.contributor.author Figueroa-Mujica, Romulo
dc.contributor.author Vizcardo-Galindo, Gustavo
dc.contributor.author Mercado, Andy
dc.contributor.author Macarlupu, Jose-Luis
dc.contributor.author Leon-Velarde, Fabiola
dc.date.accessioned 2019-02-06T14:48:07Z
dc.date.available 2019-02-06T14:48:07Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5176
dc.description.abstract Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders. Low pulse O2 saturation (SpO2) during sleep and serum androgens have been suggested to contribute to EE in CMS patients. However, whether these factors have a significant impact on the erythropoietin (Epo) system leading to EE is still unclear. We have recently shown that morning soluble Epo receptor (sEpoR), an endogenous Epo antagonist, is decreased in CMS patients suggesting increased Epo availability (increased Epo/sEpoR). The present study aimed to characterize the nocturnal concentration profile of sEpoR and Epo and their relationship with SpO2, Hct, and serum testosterone in healthy highlanders (HH) and CMS patients. Epo and sEpoR concentrations were evaluated every 4 h (6 PM to 6 AM) and nighttime SpO2 was continuously monitored (10 PM to 6 AM) in 39 male participants (CMS, n = 23; HH, n = 16) aged 21-65 yr from Cerro de Pasco, Peru (4,340 m). CMS patients showed higher serum Epo concentrations throughout the night and lower sEpoR from 10 PM to 6 AM. Consequently, Epo/sEpoR was significantly higher in the CMS group at every time point. Mean sleep-time SpO2 was lower in CMS patients compared with HH, while the percentage of sleep time spent with SpO2 < 80% was higher. Multiple-regression analysis showed mean sleep-time SpO2 and Epo/sEpoR as significant predictors of hematocrit corrected for potential confounders (age, body mass index, and testosterone). Testosterone levels were associated neither with Hct nor with erythropoietic factors. In conclusion, our results show sustained erythropoietic stimulus driven by the Epo system in CMS patients, further enhanced by a continuous exposure to accentuated nocturnal hypoxemia. en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartof urn:issn:1522-1601
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Andes en_US
dc.subject Chronic Mountain Sickness en_US
dc.subject excessive erythrocytosis en_US
dc.subject sleep en_US
dc.subject soluble erythropoietin receptor en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Altitude en_US
dc.subject Altitude Sickness/blood/metabolism/physiopathology en_US
dc.subject Androgens/blood en_US
dc.subject Chronic Disease en_US
dc.subject Hematocrit/methods en_US
dc.subject Humans en_US
dc.subject Hypoxia/blood/metabolism/physiopathology en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Oxygen/metabolism en_US
dc.subject Peru en_US
dc.subject Polycythemia/metabolism/physiopathology en_US
dc.subject Receptors, Erythropoietin/blood/metabolism en_US
dc.subject Sleep/physiology en_US
dc.subject Testosterone/blood en_US
dc.subject Young Adult en_US
dc.title Plasma soluble erythropoietin receptor is decreased during sleep in Andean highlanders with Chronic Mountain Sickness en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/japplphysiol.00107.2016
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08


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