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Chronic respiratory disease and high altitude are associated with depressive symptoms in four diverse settings

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dc.contributor.author Zaeh, S.
dc.contributor.author Miele, C. H.
dc.contributor.author Putcha, N.
dc.contributor.author Gilman, R. H.
dc.contributor.author Miranda, J. J.
dc.contributor.author Bernabe-Ortiz, A.
dc.contributor.author Wise, R. A.
dc.contributor.author Checkley, W.
dc.date.accessioned 2019-02-06T14:48:08Z
dc.date.available 2019-02-06T14:48:08Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5180
dc.description.abstract SETTING: Depression is a prevalent comorbidity of chronic respiratory disease (CRD), and may indicate worse clinical outcomes. The relationship between depression and living with chronic hypoxia due to CRD or residence at altitude has received little attention in resource-poor settings. OBJECTIVE: To investigate the association between CRD conditions and depressive symptoms in four settings in Peru. DESIGN: We collected data on CRD and depressive symptoms in adults aged 35 years. Depressive symptoms were measured according to the Center for Epidemiologic Studies Depression scale. Multivariable ordinal logistic regression was used to assess the adjusted odds of being in a higher category of depressive symptoms as a function of CRD. RESULTS: We analyzed data from 2953 participants (mean age 55.3 years, 49% male). The prevalence of major depressive symptoms was 19%, with significant variation according to setting. Participants with at least one CRD (OR 1.34, 95%CI 1.06-1.69) and those living at altitude (OR 1.64, 95%CI 1.10-2.43) had an increased adjusted odds of being in a higher category of depressive symptoms. CONCLUSION: We found a high prevalence of depressive symptoms, and a positive association between depressive symptoms with CRD and with living at altitude, both of which cause chronic hypoxia. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartof urn:issn:1815-7920
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Body Mass Index en_US
dc.subject Chronic Disease en_US
dc.subject Comorbidity en_US
dc.subject Depression/complications/epidemiology en_US
dc.subject Depressive Disorder, Major/complications/epidemiology en_US
dc.subject Educational Status en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Respiratory Tract Diseases/complications/epidemiology en_US
dc.subject Risk Factors en_US
dc.title Chronic respiratory disease and high altitude are associated with depressive symptoms in four diverse settings en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.15.0794
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07


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