dc.contributor.author |
Zelada, Henry |
|
dc.contributor.author |
Carnero, Andres-M. |
|
dc.contributor.author |
Miranda-Hurtado, Cesar |
|
dc.contributor.author |
Condezo-Aliaga, Diana |
|
dc.contributor.author |
Loza Munarriz, Cesar Antonio |
|
dc.contributor.author |
Aro Guardia, Pedro Alberto |
|
dc.contributor.author |
Manrique, Helard |
|
dc.date.accessioned |
2019-02-06T14:48:08Z |
|
dc.date.available |
2019-02-06T14:48:08Z |
|
dc.date.issued |
2016 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/5182 |
|
dc.description.abstract |
OBJECTIVE: To characterize and compare the beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes (T2D) and their non-diabetic, overweight and lean peers. METHODS: Cross-sectional study of 54 adolescents aged 10-19 years, distributed in three sex- and age-matched groups (n = 18): (i) adolescents with T2D; (ii) overweight adolescents without T2D; and (iii) lean adolescents without T2D, at the Diabetes, Obesity and Nutrition Research Center in Lima, Peru. Fasting glucose, insulin, C-peptide, and glycated hemoglobin were measured for all participants. In addition, a two-hour oral glucose tolerance test (OGTT, 1.75 mg of glucose/kg body weight) was performed, during which glucose and C-peptide were quantified. The homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) were derived for all participants, and beta-cell function was further examined by the area under the curve (AUC) of C-peptide. RESULTS: The median HOMA-IR score was higher in adolescents with T2D compared to lean adolescents (6.1 vs. 2.1; p = 0.002), but was not different from that of overweight adolescents (6.1 vs. 4.0; p = 0.322). The median HOMA-B was higher in overweight adolescents than in lean adolescents (256.9 vs. 134.2; p = 0.015), and adolescents with T2D (256.9 vs. 119.8; p = 0.011). The mean AUC of glucose in adolescents with T2D was 1.8-fold higher than that of overweight adolescents, and 1.9-fold higher than that of lean adolescents (p < 0.001). Although the median AUC of C-peptide in adolescents with T2D was lower than that of overweight and lean adolescents, this difference was not statistically significant (230.7 vs. 336.6 vs. 267.3 nmol/l120 min, respectively; p = 0.215). CONCLUSION: Among Peruvian adolescents with T2D, insulin resistance is the most prominent characteristic, rather than beta-cell dysfunction. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Journal of Clinical and Translational Endocrinology |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Adolescent |
en_US |
dc.subject |
Insulin resistance |
en_US |
dc.subject |
Obesity |
en_US |
dc.subject |
Pancreatic beta cells |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
Type 2 diabetes |
en_US |
dc.title |
Beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.jcte.2016.05.003 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.18 |
|
dc.relation.issn |
2214-6237 |
|