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Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis

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dc.contributor.author Bustos, Javier-A.
dc.contributor.author Garcia, Hector-H.
dc.contributor.author Del-Brutto, Oscar-H.
dc.date.accessioned 2019-02-06T14:51:17Z
dc.date.available 2019-02-06T14:51:17Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5196
dc.description.abstract INTRODUCTION: Neurocysticercosis (NCC) is a leading causes of secondary epilepsy worldwide. There is increasing evidence on the epileptogenic role of NCC, and the presence of edema, calcified scars, gliosis and hippocampal sclerosis support this phenomenon. AREAS COVERED: We summarized principles of antiepileptic drug (AED) therapy as well as risk factors associated with seizure recurrence after AED withdrawal in patients with NCC. Expert commentary: First-line AED monotherapy is effective as a standard approach to control seizures in most NCC patients. Risks and benefits of AED withdrawal have not been systematically studied, and this decision must be individualized. However, a seizure-free period of at least two years seem prudent before attempting withdrawal. Risk factors for seizure recurrence after AED withdrawal include a history of status epilepticus, poor seizure control during treatment, neuroimaging evidence of perilesional gliosis, hippocampal sclerosis and calcified lesions, as well as persistence of paroxysmal activity in the EEG. en_US
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof urn:issn:1744-8360
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject antiepileptic drug withdrawal en_US
dc.subject cysticercosis en_US
dc.subject epilepsy en_US
dc.subject Neurocysticercosis en_US
dc.subject seizures en_US
dc.subject Anticonvulsants/therapeutic use en_US
dc.subject Epilepsy/drug therapy/etiology en_US
dc.subject Humans en_US
dc.subject Neurocysticercosis/complications en_US
dc.subject Neuroimaging en_US
dc.subject Recurrence en_US
dc.subject Seizures/drug therapy/etiology en_US
dc.subject Withholding Treatment en_US
dc.title Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1080/14737175.2016.1194757


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