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Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus

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dc.contributor.author Del-Brutto, Oscar-H.
dc.contributor.author Engel, Jerome-Jr
dc.contributor.author Eliashiv, Dawn-S.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-02-06T14:51:18Z
dc.date.available 2019-02-06T14:51:18Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5205
dc.description.abstract Neurocysticercosis (NCC) is the most common helminthic infection of the nervous system and a frequent cause of reactive seizures and epilepsy worldwide. In many cases, multiple episodes of focal seizures related to an identifiable parenchymal brain cyst (and likely attributable to local damage) continue for years after the cyst resolves. However, cases where seizure semiology, interictal EEG abnormalities, and parasites location do not correlate raise concerns about the causal relationship between NCC and either reactive seizures or epilepsy, as well as the epileptogenic potential of parasites. Neurosurgical series of patients with intractable epilepsy and cross-sectional population-based studies have shown a robust association between NCC and hippocampal sclerosis (HS), which might contribute to the above-referred inconsistencies. Current information does not allow to define whether in patients with NCC, HS could result from recurrent seizure activity from a local or distant focus or from chronic recurrent inflammation. In either case, HS may become the pathological substrate of subsequent mesial temporal lobe epilepsy (MTLE). Longitudinal clinical- and population-based cohort studies are needed to evaluate the causal relationship between NCC and HS and to characterize this association with the occurrence of MTLE. If a cause-and-effect relationship between NCC and HS is demonstrated, NCC patients could be assessed to examine neuronal mechanisms of hippocampal epileptogenesis in comparison with animal models, to identify biomarkers of hippocampal epileptogenesis, and to develop novel interventions to prevent epilepsy in NCC and perhaps in other forms of acquired epilepsy. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Current Neurology and Neuroscience Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Hippocampus en_US
dc.subject Animals en_US
dc.subject Cysticercosis en_US
dc.subject Epilepsy en_US
dc.subject Epilepsy/etiology/physiopathology en_US
dc.subject Hippocampal sclerosis en_US
dc.subject Hippocampus en_US
dc.subject Humans en_US
dc.subject Neurocysticercosis en_US
dc.subject Neurocysticercosis/complications en_US
dc.subject Sclerosis/complications en_US
dc.subject Seizures en_US
dc.subject Seizures/physiopathology en_US
dc.title Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s11910-015-0601-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1534-6293


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