Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus

García Lescano, Héctor Hugo; Engel, Jerome-Jr; Del-Brutto, Oscar-H.; Eliashiv, Dawn-S.

dc.contributor.author	Del-Brutto, Oscar-H.
dc.contributor.author	Engel, Jerome-Jr
dc.contributor.author	Eliashiv, Dawn-S.
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2019-02-06T14:51:18Z
dc.date.available	2019-02-06T14:51:18Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5205
dc.description.abstract	Neurocysticercosis (NCC) is the most common helminthic infection of the nervous system and a frequent cause of reactive seizures and epilepsy worldwide. In many cases, multiple episodes of focal seizures related to an identifiable parenchymal brain cyst (and likely attributable to local damage) continue for years after the cyst resolves. However, cases where seizure semiology, interictal EEG abnormalities, and parasites location do not correlate raise concerns about the causal relationship between NCC and either reactive seizures or epilepsy, as well as the epileptogenic potential of parasites. Neurosurgical series of patients with intractable epilepsy and cross-sectional population-based studies have shown a robust association between NCC and hippocampal sclerosis (HS), which might contribute to the above-referred inconsistencies. Current information does not allow to define whether in patients with NCC, HS could result from recurrent seizure activity from a local or distant focus or from chronic recurrent inflammation. In either case, HS may become the pathological substrate of subsequent mesial temporal lobe epilepsy (MTLE). Longitudinal clinical- and population-based cohort studies are needed to evaluate the causal relationship between NCC and HS and to characterize this association with the occurrence of MTLE. If a cause-and-effect relationship between NCC and HS is demonstrated, NCC patients could be assessed to examine neuronal mechanisms of hippocampal epileptogenesis in comparison with animal models, to identify biomarkers of hippocampal epileptogenesis, and to develop novel interventions to prevent epilepsy in NCC and perhaps in other forms of acquired epilepsy.	en_US
dc.language.iso	eng
dc.publisher	Springer
dc.relation.ispartofseries	Current Neurology and Neuroscience Reports
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Hippocampus	en_US
dc.subject	Animals	en_US
dc.subject	Cysticercosis	en_US
dc.subject	Epilepsy	en_US
dc.subject	Epilepsy/etiology/physiopathology	en_US
dc.subject	Hippocampal sclerosis	en_US
dc.subject	Hippocampus	en_US
dc.subject	Humans	en_US
dc.subject	Neurocysticercosis	en_US
dc.subject	Neurocysticercosis/complications	en_US
dc.subject	Sclerosis/complications	en_US
dc.subject	Seizures	en_US
dc.subject	Seizures/physiopathology	en_US
dc.title	Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1007/s11910-015-0601-x
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn	1534-6293