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Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

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dc.contributor.author Hupalo, Daniel-N.
dc.contributor.author Luo, Zunping
dc.contributor.author Melnikov, Alexandre
dc.contributor.author Sutton, Patrick-L.
dc.contributor.author Rogov, Peter
dc.contributor.author Escalante, Ananias
dc.contributor.author Vallejo, Andres-F.
dc.contributor.author Herrera, Socrates
dc.contributor.author Arevalo-Herrera, Myriam
dc.contributor.author Fan, Qi
dc.contributor.author Wang, Ying
dc.contributor.author Cui, Liwang
dc.contributor.author Lucas, Carmen-M.
dc.contributor.author Durand, Salomon
dc.contributor.author Sanchez, Juan-F.
dc.contributor.author Baldeviano, G. Christian
dc.contributor.author Lescano, Andres-G.
dc.contributor.author Laman, Moses
dc.contributor.author Barnadas, Celine
dc.contributor.author Barry, Alyssa
dc.contributor.author Mueller, Ivo
dc.contributor.author Kazura, James-W.
dc.contributor.author Eapen, Alex
dc.contributor.author Kanagaraj, Deena
dc.contributor.author Valecha, Neena
dc.contributor.author Ferreira, Marcelo-U.
dc.contributor.author Roobsoong, Wanlapa
dc.contributor.author Nguitragool, Wang
dc.contributor.author Sattabonkot, Jetsumon
dc.contributor.author Gamboa, Dionicia
dc.contributor.author Kosek, Margaret
dc.contributor.author Vinetz, Joseph-M.
dc.contributor.author Gonzalez-Ceron, Lilia
dc.contributor.author Birren, Bruce-W.
dc.contributor.author Neafsey, Daniel-E.
dc.contributor.author Carlton, Jane-M.
dc.date.accessioned 2019-02-06T14:51:20Z
dc.date.available 2019-02-06T14:51:20Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5220
dc.description.abstract Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1546-1718
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Antimalarials/pharmacology en_US
dc.subject Drug Resistance/genetics en_US
dc.subject Genetic Markers/genetics en_US
dc.subject Humans en_US
dc.subject Malaria, Vivax/drug therapy/genetics/parasitology en_US
dc.subject Metagenomics/methods en_US
dc.subject Plasmodium vivax/drug effects/genetics/pathogenicity en_US
dc.subject Selection, Genetic/drug effects/genetics en_US
dc.subject Transcriptome/genetics en_US
dc.title Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/ng.3588
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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