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Hair follicle characteristics as early marker of Type 2 Diabetes

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dc.contributor.author Miranda, J. Jaime
dc.contributor.author Taype-Rondan, Alvaro
dc.contributor.author Tapia, Jose-Carlos
dc.contributor.author Gastanadui-Gonzalez, Maria-Gabriela
dc.contributor.author Roman-Carpio, Ricardo
dc.date.accessioned 2019-02-06T14:51:22Z
dc.date.available 2019-02-06T14:51:22Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5231
dc.description.abstract Type 2 Diabetes mellitus (DM2) includes a continuum of metabolic disorders characterized by hyperglycemia that causes several chronic long-term complications such as coronary artery disease, peripheral arterial disease, nephropathy, and neuropathy. The hair follicle could reveal signs of early vascular impairment, yet its relationship to early metabolic injuries has been largely ignored. We propose that in earlier stages of the continuum of DM2-related metabolic disorders, a group of susceptible patients who do not yet meet the diagnostic criteria to be considered as persons with DM2 may present chronic vascular impairment and end organ damage, including hair follicle damage, which can be evaluated to identify an early risk marker. This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. In order to test this hypothesis, studies are required to evaluate if hair follicle characteristics are related to and can predict hyperglycemic complications, and if they do so, which feature of the hair follicle, such as hair growth, best characterizes such DM2-related conditions. If this hypothesis were proven to be true, significant advances towards a personalized approach for early prevention strategies and management of DM2 would be made. By focusing on the hair follicles, early stages of metabolic-related organ damage could be identified using non-invasive low-cost techniques. In so doing, this approach could provide early identification of DM2-susceptible individuals and lead to the early initiation of adequate primary prevention strategies to reduce or avoid the onset of large internal organ damage. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Medical Hypotheses
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Aging en_US
dc.subject Alopecia/complications en_US
dc.subject Amino Acids/blood/metabolism en_US
dc.subject Autoimmune Diseases/complications en_US
dc.subject Diabetes Mellitus, Type 2/blood/diagnosis en_US
dc.subject Disease Progression en_US
dc.subject Ethnic Groups en_US
dc.subject Female en_US
dc.subject Hair Follicle/physiopathology en_US
dc.subject Hair/physiology en_US
dc.subject Humans en_US
dc.subject Hyperglycemia/blood en_US
dc.subject Insulin Resistance en_US
dc.subject Male en_US
dc.subject Models, Theoretical en_US
dc.subject Research Design en_US
dc.subject Risk en_US
dc.subject Seasons en_US
dc.title Hair follicle characteristics as early marker of Type 2 Diabetes en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.mehy.2016.08.009
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 1532-2777


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