Hair follicle characteristics as early marker of Type 2 Diabetes

Tapia, Jose-Carlos; Taype-Rondan, Alvaro; Miranda, J. Jaime; Roman-Carpio, Ricardo; Gastanadui-Gonzalez, Maria-Gabriela

dc.contributor.author	Miranda, J. Jaime
dc.contributor.author	Taype-Rondan, Alvaro
dc.contributor.author	Tapia, Jose-Carlos
dc.contributor.author	Gastanadui-Gonzalez, Maria-Gabriela
dc.contributor.author	Roman-Carpio, Ricardo
dc.date.accessioned	2019-02-06T14:51:22Z
dc.date.available	2019-02-06T14:51:22Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5231
dc.description.abstract	Type 2 Diabetes mellitus (DM2) includes a continuum of metabolic disorders characterized by hyperglycemia that causes several chronic long-term complications such as coronary artery disease, peripheral arterial disease, nephropathy, and neuropathy. The hair follicle could reveal signs of early vascular impairment, yet its relationship to early metabolic injuries has been largely ignored. We propose that in earlier stages of the continuum of DM2-related metabolic disorders, a group of susceptible patients who do not yet meet the diagnostic criteria to be considered as persons with DM2 may present chronic vascular impairment and end organ damage, including hair follicle damage, which can be evaluated to identify an early risk marker. This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. In order to test this hypothesis, studies are required to evaluate if hair follicle characteristics are related to and can predict hyperglycemic complications, and if they do so, which feature of the hair follicle, such as hair growth, best characterizes such DM2-related conditions. If this hypothesis were proven to be true, significant advances towards a personalized approach for early prevention strategies and management of DM2 would be made. By focusing on the hair follicles, early stages of metabolic-related organ damage could be identified using non-invasive low-cost techniques. In so doing, this approach could provide early identification of DM2-susceptible individuals and lead to the early initiation of adequate primary prevention strategies to reduce or avoid the onset of large internal organ damage.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Medical Hypotheses
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Aging	en_US
dc.subject	Alopecia/complications	en_US
dc.subject	Amino Acids/blood/metabolism	en_US
dc.subject	Autoimmune Diseases/complications	en_US
dc.subject	Diabetes Mellitus, Type 2/blood/diagnosis	en_US
dc.subject	Disease Progression	en_US
dc.subject	Ethnic Groups	en_US
dc.subject	Female	en_US
dc.subject	Hair Follicle/physiopathology	en_US
dc.subject	Hair/physiology	en_US
dc.subject	Humans	en_US
dc.subject	Hyperglycemia/blood	en_US
dc.subject	Insulin Resistance	en_US
dc.subject	Male	en_US
dc.subject	Models, Theoretical	en_US
dc.subject	Research Design	en_US
dc.subject	Risk	en_US
dc.subject	Seasons	en_US
dc.title	Hair follicle characteristics as early marker of Type 2 Diabetes	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.mehy.2016.08.009
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn	1532-2777