Universidad Peruana Cayetano Heredia

Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE

Mostrar el registro sencillo del ítem

dc.contributor.author Nguyen, H. Bryant
dc.contributor.author Jaehne, Anja-Kathrin
dc.contributor.author Jayaprakash, Namita
dc.contributor.author Semler, Matthew-W.
dc.contributor.author Hegab, Sara
dc.contributor.author Yataco, Angel-Coz
dc.contributor.author Tatem, Geneva
dc.contributor.author Salem, Dhafer
dc.contributor.author Moore, Steven
dc.contributor.author Boka, Kamran
dc.contributor.author Gill, Jasreen-Kaur
dc.contributor.author Gardner-Gray, Jayna
dc.contributor.author Pflaum, Jacqueline
dc.contributor.author Domecq, Juan-Pablo
dc.contributor.author Hurst, Gina
dc.contributor.author Belsky, Justin-B.
dc.contributor.author Fowkes, Raymond
dc.contributor.author Elkin, Ronald-B.
dc.contributor.author Simpson, Steven-Q.
dc.contributor.author Falk, Jay-L.
dc.contributor.author Singer, Daniel-J.
dc.contributor.author Rivers, Emanuel-P.
dc.date.accessioned 2019-02-06T14:51:42Z
dc.date.available 2019-02-06T14:51:42Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5235
dc.description.abstract Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called early goal-directed therapy was compared to standard care and this clinical trial resulted in a significant mortality reduction. Since the publication of that trial, similar outcome benefits have been reported in over 70 observational and randomized controlled studies comprising over 70,000 patients. As a result, early goal-directed therapy was largely incorporated into the first 6 hours of sepsis management (resuscitation bundle) adopted by the Surviving Sepsis Campaign and disseminated internationally as the standard of care for early sepsis management. Recently a trio of trials (ProCESS, ARISE, and ProMISe), while reporting an all-time low sepsis mortality, question the continued need for all of the elements of early goal-directed therapy or the need for protocolized care for patients with severe and septic shock. A review of the early hemodynamic pathogenesis, historical development, and definition of early goal-directed therapy, comparing trial conduction methodology and the changing landscape of sepsis mortality, are essential for an appropriate interpretation of these trials and their conclusions. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Critical Care
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Patient Care Planning en_US
dc.subject Hemodynamics/physiology en_US
dc.subject Humans en_US
dc.subject Resuscitation/methods en_US
dc.subject Sepsis/mortality/physiopathology/therapy en_US
dc.subject Shock, Septic/mortality/physiopathology/therapy en_US
dc.title Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1186/s13054-016-1288-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.09
dc.relation.issn 1466-609X


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas