Universidad Peruana Cayetano Heredia

Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice

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dc.contributor.author Pichon, Aurelien
dc.contributor.author Jeton, Florine
dc.contributor.author El-Hasnaoui-Saadani, Raja
dc.contributor.author Hagstrom, Luciana
dc.contributor.author Launay, Thierry
dc.contributor.author Beaudry, Michele
dc.contributor.author Marchant, Dominique
dc.contributor.author Quidu, Patricia
dc.contributor.author Macarlupu, Jose-Luis
dc.contributor.author Favret, Fabrice
dc.contributor.author Richalet, Jean-Paul
dc.contributor.author Voituron, Nicolas
dc.date.accessioned 2019-02-06T14:51:43Z
dc.date.available 2019-02-06T14:51:43Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5240
dc.description.abstract Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. The presence of Epo/Epo receptors in these organs suggests other roles than those usually assigned to this protein. Thus, the aim of this review is to describe the effects of Epo deficiency on adaptation to normoxic and hypoxic environments and to suggest a key role of Epo on main physiological adaptive functions. Our original model of Epo-deficient (Epo-TAg(h)) mice allowed us to improve our knowledge of the possible role of Epo in O2 homeostasis. The use of anemic transgenic mice revealed Epo as a crucial component of adaptation to hypoxia. Epo-TAg(h) mice survive well in hypoxic conditions despite low hematocrit. Furthermore, Epo plays a key role in neural control of ventilatory acclimatization and response to hypoxia, in deformability of red blood cells, in cerebral and cardiac angiogenesis, and in neuro- and cardioprotection. en_US
dc.language.iso eng
dc.publisher Dove Medical Press
dc.relation.ispartofseries Hypoxia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Epo-TAgh mice en_US
dc.subject hypoxia en_US
dc.subject mouse model en_US
dc.subject physiological functions en_US
dc.title Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.2147/HP.S83540
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 2324-1128


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