Universidad Peruana Cayetano Heredia

Protocol for studying cough frequency in people with pulmonary tuberculosis

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dc.contributor.author Proaño, Alvaro
dc.contributor.author Bravard, Marjory A.
dc.contributor.author Tracey, Brian H.
dc.contributor.author Lopez, Jose W.
dc.contributor.author Comina, German
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Coronel, Jorge
dc.contributor.author Lee, Gwenyth O'Neil
dc.contributor.author Caviedes, Luz
dc.contributor.author Cabrera, Jose Luis
dc.contributor.author Salas, Antonio
dc.contributor.author Ticona, Eduardo
dc.contributor.author Kirwan, Daniela E.
dc.contributor.author Friedland, Jon S.
dc.contributor.author Evans, Carlton Anthony William
dc.contributor.author Moore, David Alexander James
dc.contributor.author Gilman, Robert Hugh
dc.date.accessioned 2019-02-06T14:51:43Z
dc.date.available 2019-02-06T14:51:43Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5241
dc.description.abstract INTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 1969. The main aim of this study is to describe cough frequency patterns before and after the start of TB treatment and to determine baseline factors that affect cough frequency in these patients. Secondarily, we will evaluate the correlation between cough frequency and TB microbiological resolution. METHODS: This study will select participants with culture confirmed TB from 2 tertiary hospitals in Lima, Peru. We estimated that a sample size of 107 patients was sufficient to detect clinically significant changes in cough frequency. Participants will initially be evaluated through questionnaires, radiology, microscopic observation drug susceptibility broth TB-culture, auramine smear microscopy and cough recordings. This cohort will be followed for the initial 60 days of anti-TB treatment, and throughout the study several microbiological samples as well as 24 h recordings will be collected. We will describe the variability of cough episodes and determine its association with baseline laboratory parameters of pulmonary TB. In addition, we will analyse the reduction of cough frequency in predicting TB cure, adjusted for potential confounders. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the ethics committees at each participating hospital in Lima, Peru, Asociacion Benefica PRISMA in Lima, Peru, the Universidad Peruana Cayetano Heredia in Lima, Peru and Johns Hopkins University in Baltimore, USA. We aim to publish and disseminate our findings in peer-reviewed journals. We also expect to create and maintain an online repository for TB cough sounds as well as the statistical analysis employed. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries BMJ Open
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cough en_US
dc.subject Monitoring en_US
dc.subject Adult en_US
dc.subject Antitubercular Agents/therapeutic use en_US
dc.subject Clinical Protocols en_US
dc.subject Cough/microbiology/physiopathology en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Peru en_US
dc.subject Predictive Value of Tests en_US
dc.subject Prospective Studies en_US
dc.subject Tuberculosis, Pulmonary/complications/drug therapy/physiopathology en_US
dc.title Protocol for studying cough frequency in people with pulmonary tuberculosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/bmjopen-2015-010365
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 2044-6055


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