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Treat to target in systemic lupus erythematosus: a commentary

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Burgos, Paula-I.
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2019-02-06T14:51:45Z
dc.date.available 2019-02-06T14:51:45Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5253
dc.description.abstract Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease activity, improve health-related quality of life, and reduce morbidity and mortality. Remission would be the main target, but a low disease activity state (LDAS) could be an acceptable alternative. However, due to SLE protean manifestations, the operational definitions of both remission and LDAS are still in progress. The definitions of these targets, remission and LDAS, should include a validated disease activity index, the treatments allowed, and the minimum length of time the target should be maintained. Furthermore, achieving these targets should result in better disease outcomes such as reducing damage accrual. This review addresses the current state regarding these possible targets in SLE and the impact of achieving them in intermediate and long-term outcomes of this disease. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Clinical Rheumatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Severity of Illness Index en_US
dc.subject Antimalarials/therapeutic use en_US
dc.subject Humans en_US
dc.subject Immunosuppressive Agents/therapeutic use en_US
dc.subject Lupus Erythematosus, Systemic/therapy en_US
dc.subject Outcome en_US
dc.subject Prednisone/therapeutic use en_US
dc.subject Quality of Life en_US
dc.subject Remission en_US
dc.subject Remission Induction/methods en_US
dc.subject Systemic lupus erythematosus en_US
dc.subject Therapy en_US
dc.subject Treatment Outcome en_US
dc.title Treat to target in systemic lupus erythematosus: a commentary en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1007/s10067-016-3346-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1434-9949


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