Universidad Peruana Cayetano Heredia

Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level

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dc.contributor.author Pomeroy, Emma
dc.contributor.author Wells, Jonathan C. K.
dc.contributor.author Stanojevic, Sanja
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Moore, Lorna G.
dc.contributor.author Cole, Tim J.
dc.contributor.author Stock, Jay T.
dc.date.accessioned 2019-02-06T14:52:12Z
dc.date.available 2019-02-06T14:52:12Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5263
dc.description.abstract OBJECTIVES: Native Andean ancestry gives partial protection from reduced birthweight at high altitude in the Andes compared with European ancestry. Whether Andean ancestry is also associated with body proportions and greater postnatal body size at altitude is unknown. Therefore, we tested whether a greater proportion of Andean ancestry is associated with stature and body proportions among Peruvian children at high and low altitude. METHODS: Height, head circumference, head-trunk height, upper and lower limb lengths, and tibia, ulna, hand and foot lengths, were measured in 133 highland and 169 lowland children aged 6 months to 8.5 years. For highland and lowland groups separately, age-sex-adjusted anthropometry z scores were regressed on the number of indigenous parental surnames as a proxy for Andean ancestry, adjusting for potential confounders (maternal age and education, parity, altitude [highlands only]). RESULTS: Among highland children, greater Andean ancestry was negatively associated with stature and tibia, ulna, and lower limb lengths, independent of negative associations with greater altitude for these measurements. Relationships were strongest for tibia length: each additional Andean surname or 1,000 m increase at altitude among highland children was associated with 0.18 and 0.65 z score decreases in tibia length, respectively. Anthropometry was not significantly associated with ancestry among lowland children. CONCLUSIONS: Greater Andean ancestry is associated with shorter stature and limb measurements at high but not low altitude. Gene-environment interactions between high altitude and Andean ancestry may exacerbate the trade-off between chest dimensions and stature that was proposed previously, though we could not test this directly. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries American Journal of Human Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Infant en_US
dc.subject Socioeconomic Factors en_US
dc.subject Altitude en_US
dc.subject Indians, South American en_US
dc.subject Body Weights and Measures en_US
dc.subject Child Development en_US
dc.subject Gene-Environment Interaction en_US
dc.title Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/ajhb.22725
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.01
dc.relation.issn 1520-6300


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