Aerobic capacity of Peruvian Quechua: a test of the developmental adaptation hypothesis

León-Velarde, Fabiola; Elías, Gianpietro; Brutsaert, Tom D.; Rivera Chira, Maria Concepcion; Kiyamu Tsuchiya, Melisa

dc.contributor.author	Kiyamu Tsuchiya, Melisa
dc.contributor.author	Brutsaert, Tom D.
dc.contributor.author	Elías, Gianpietro
dc.contributor.author	León-Velarde, Fabiola
dc.contributor.author	Rivera Chira, Maria Concepcion
dc.date.accessioned	2019-02-06T14:52:12Z
dc.date.available	2019-02-06T14:52:12Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5265
dc.description.abstract	High altitude natives are reported to have outstanding work capacity in spite of the challenge of oxygen transport and delivery in hypoxia. To evaluate the developmental effect of lifelong exposure to hypoxia on aerobic capacity, VO2peak was measured on two groups of Peruvian Quechua subjects (18-35 years), who differed in their developmental exposure to altitude. Male and female volunteers were recruited in Lima, Peru (150 m), and were divided in two groups, based on their developmental exposure to hypoxia, those: a) Born at sea-level individuals (BSL), with no developmental exposure to hypoxia (n = 34) and b) Born at high-altitude individuals (BHA) with full developmental exposure to hypoxia (n = 32), but who migrated to sea-level as adults (>16-years-old). Tests were conducted both in normoxia (BP = 750 mm Hg) and normobaric hypoxia at sea-level (BP = 750 mm Hg, FiO2 = 0.12, equivalent to 4,449 m), after a 2-month training period (in order to control for initial differences in physical fitness) at sea-level. BHA had a significantly higher VO2peak at hypoxia (40.31 +/- 1.0 ml/min/kg) as compared to BSL (35.78 +/- 0.96 ml/min/kg, P = 0.001), adjusting for sex. The decrease of VO2peak at HA relative to SL (DeltaVO2peak ) was not different between groups, controlling for baseline levels (VO2peak at sea-level) and sex (BHA = 0.35 +/- 0.04 l/min, BSL = 0.44 +/- 0.04 l/min; P = 0.12). Forced vital capacity (controlling for height) and the residuals of VO2peak (controlling for weight) had a significant association in the BHA group only (r = 0.155; P = 0.031). In sum, results indicate that developmental exposure to altitude constitutes an important factor to determine superior exercise performance.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Physical Anthropology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Peru	en_US
dc.subject	Adolescent	en_US
dc.subject	Adult	en_US
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Young Adult	en_US
dc.subject	hypoxia	en_US
dc.subject	adaptation	en_US
dc.subject	Hypoxia	en_US
dc.subject	development	en_US
dc.subject	Acclimatization/physiology	en_US
dc.subject	Exercise/physiology	en_US
dc.subject	Oxygen Consumption/physiology	en_US
dc.subject	Hemoglobins/analysis	en_US
dc.subject	Anthropology, Physical	en_US
dc.subject	exercise	en_US
dc.subject	Oxygen/blood/metabolism	en_US
dc.title	Aerobic capacity of Peruvian Quechua: a test of the developmental adaptation hypothesis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/ajpa.22655
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn	1096-8644