Universidad Peruana Cayetano Heredia

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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dc.contributor.author Vargas-Calla, Ana
dc.contributor.author Gomez-Puerta, Luis A.
dc.contributor.author Calcina, Juan
dc.contributor.author Gonzales-Viera, Omar
dc.contributor.author Gavidia, Cesar
dc.contributor.author Lopez-Urbina, Maria T.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.date.accessioned 2019-02-06T14:52:14Z
dc.date.available 2019-02-06T14:52:14Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5274
dc.description.abstract OBJECTIVE: To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis. METHODS: Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups. RESULTS: All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation. CONCLUSIONS: TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Asian Pacific Journal of Tropical Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cysticercosis en_US
dc.subject Taenia solium en_US
dc.subject Treatment en_US
dc.subject Oxfendazole en_US
dc.subject Triclabendazole en_US
dc.title Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.apjtm.2015.12.005
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 2352-4146


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