dc.contributor.author |
Lazo Porras, María de los Ángeles |
|
dc.contributor.author |
Bernabé Ortiz, Antonio |
|
dc.contributor.author |
Málaga Rodríguez, Germán Javier |
|
dc.contributor.author |
Gilman, Robert Hugh |
|
dc.contributor.author |
Acuna-Villaorduna, Ana |
|
dc.contributor.author |
Cardenas-Montero, Deborah |
|
dc.contributor.author |
Smeeth, Liam |
|
dc.contributor.author |
Miranda, J. Jaime |
|
dc.date.accessioned |
2019-02-06T14:52:14Z |
|
dc.date.available |
2019-02-06T14:52:14Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/5275 |
|
dc.description.abstract |
Introduction. Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective. Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods. Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results. Data from 988 participants, rural (n = 201), rural-to-urban migrants (n = 589), and urban (n = 199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%–59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR = 3.46; 95%CI: 1.23–9.74). Conclusions. Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold the 5-year risk of cardiovascular outcomes. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Atherosclerosis |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Adult |
en_US |
dc.subject |
Female |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Male |
en_US |
dc.subject |
Odds Ratio |
en_US |
dc.subject |
Time Factors |
en_US |
dc.subject |
Cross-Sectional Studies |
en_US |
dc.subject |
Middle Aged |
en_US |
dc.subject |
Peru/epidemiology |
en_US |
dc.subject |
Prevalence |
en_US |
dc.subject |
Risk Factors |
en_US |
dc.subject |
Multivariate Analysis |
en_US |
dc.subject |
Longitudinal Studies |
en_US |
dc.subject |
Risk Assessment |
en_US |
dc.subject |
Mortality |
en_US |
dc.subject |
Stroke |
en_US |
dc.subject |
Cholesterol |
en_US |
dc.subject |
Comorbidity |
en_US |
dc.subject |
Age Distribution |
en_US |
dc.subject |
Sex Distribution |
en_US |
dc.subject |
Biomarkers/blood |
en_US |
dc.subject |
Rural Health |
en_US |
dc.subject |
Transients and Migrants |
en_US |
dc.subject |
Urban Health |
en_US |
dc.subject |
Cholesterol, HDL/blood |
en_US |
dc.subject |
Down-Regulation |
en_US |
dc.subject |
Dyslipidemias/blood/diagnosis/epidemiology/mortality |
en_US |
dc.subject |
HDL |
en_US |
dc.subject |
Human migration |
en_US |
dc.subject |
Life Style |
en_US |
dc.subject |
Myocardial infarction |
en_US |
dc.subject |
Myocardial Infarction/diagnosis/epidemiology/mortality |
en_US |
dc.subject |
Stroke/diagnosis/epidemiology/mortality |
en_US |
dc.title |
Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.atherosclerosis.2015.12.039 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.04 |
|
dc.relation.issn |
1879-1484 |
|