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dc.contributor.author | Lazo Porras, María de los Ángeles | |
dc.contributor.author | Bernabé Ortiz, Antonio | |
dc.contributor.author | Málaga Rodríguez, Germán Javier | |
dc.contributor.author | Gilman, Robert Hugh | |
dc.contributor.author | Acuna-Villaorduna, Ana | |
dc.contributor.author | Cardenas-Montero, Deborah | |
dc.contributor.author | Smeeth, Liam | |
dc.contributor.author | Miranda, J. Jaime | |
dc.date.accessioned | 2019-02-06T14:52:14Z | |
dc.date.available | 2019-02-06T14:52:14Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/5275 | |
dc.description.abstract | Introduction. Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective. Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods. Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results. Data from 988 participants, rural (n = 201), rural-to-urban migrants (n = 589), and urban (n = 199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%–59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR = 3.46; 95%CI: 1.23–9.74). Conclusions. Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold the 5-year risk of cardiovascular outcomes. | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Atherosclerosis | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Adult | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Odds Ratio | en_US |
dc.subject | Time Factors | en_US |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Peru/epidemiology | en_US |
dc.subject | Prevalence | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Multivariate Analysis | en_US |
dc.subject | Longitudinal Studies | en_US |
dc.subject | Risk Assessment | en_US |
dc.subject | Mortality | en_US |
dc.subject | Stroke | en_US |
dc.subject | Cholesterol | en_US |
dc.subject | Comorbidity | en_US |
dc.subject | Age Distribution | en_US |
dc.subject | Sex Distribution | en_US |
dc.subject | Biomarkers/blood | en_US |
dc.subject | Rural Health | en_US |
dc.subject | Transients and Migrants | en_US |
dc.subject | Urban Health | en_US |
dc.subject | Cholesterol, HDL/blood | en_US |
dc.subject | Down-Regulation | en_US |
dc.subject | Dyslipidemias/blood/diagnosis/epidemiology/mortality | en_US |
dc.subject | HDL | en_US |
dc.subject | Human migration | en_US |
dc.subject | Life Style | en_US |
dc.subject | Myocardial infarction | en_US |
dc.subject | Myocardial Infarction/diagnosis/epidemiology/mortality | en_US |
dc.subject | Stroke/diagnosis/epidemiology/mortality | en_US |
dc.title | Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.atherosclerosis.2015.12.039 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.04 | |
dc.relation.issn | 1879-1484 |
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