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Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study

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dc.contributor.author Lazo-Porras, Maria
dc.contributor.author Bernabe-Ortiz, Antonio
dc.contributor.author Malaga, German
dc.contributor.author Gilman, Robert H.
dc.contributor.author Acuna-Villaorduna, Ana
dc.contributor.author Cardenas-Montero, Deborah
dc.contributor.author Smeeth, Liam
dc.contributor.author Miranda, J. Jaime
dc.date.accessioned 2019-02-06T14:52:14Z
dc.date.available 2019-02-06T14:52:14Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5275
dc.description.abstract Introduction. Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective. Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods. Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results. Data from 988 participants, rural (n = 201), rural-to-urban migrants (n = 589), and urban (n = 199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%–59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR = 3.46; 95%CI: 1.23–9.74). Conclusions. Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold the 5-year risk of cardiovascular outcomes. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1879-1484
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Odds Ratio en_US
dc.subject Time Factors en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject Multivariate Analysis en_US
dc.subject Longitudinal Studies en_US
dc.subject Risk Assessment en_US
dc.subject Mortality en_US
dc.subject Stroke en_US
dc.subject Cholesterol en_US
dc.subject Comorbidity en_US
dc.subject Age Distribution en_US
dc.subject Sex Distribution en_US
dc.subject Biomarkers/blood en_US
dc.subject Rural Health en_US
dc.subject Transients and Migrants en_US
dc.subject Urban Health en_US
dc.subject Cholesterol, HDL/blood en_US
dc.subject Down-Regulation en_US
dc.subject Dyslipidemias/blood/diagnosis/epidemiology/mortality en_US
dc.subject HDL en_US
dc.subject Human migration en_US
dc.subject Life Style en_US
dc.subject Myocardial infarction en_US
dc.subject Myocardial Infarction/diagnosis/epidemiology/mortality en_US
dc.subject Stroke/diagnosis/epidemiology/mortality en_US
dc.title Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.atherosclerosis.2015.12.039
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04


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