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Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

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dc.contributor.author Hernández, Wilfredo
dc.contributor.author Paz, Juan
dc.contributor.author Carrasco, Fernando
dc.contributor.author Vaisberg Wollach, Abraham Jaime
dc.contributor.author Spodine, Evgenia
dc.contributor.author Manzur, Jorge
dc.contributor.author Hennig, Lothar
dc.contributor.author Sieler, Joachim
dc.contributor.author Blaurock, Steffen
dc.contributor.author Beyer, Lothar
dc.date.accessioned 2019-02-06T14:52:14Z
dc.date.available 2019-02-06T14:52:14Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/5277
dc.description.abstract The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes ((IC50 = 0.01–9.87 𝜇M) exhibited higher antiproliferative activity than their free ligands ((IC50 = 23.48–70.86 and >250 𝜇M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 𝜇M, resp.). en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries Bioinorganic Chemistry and Applications
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Palladium(II) Thiosemicarbazone en_US
dc.subject Cytotoxic Activity en_US
dc.subject Human Tumor Cell Lines en_US
dc.title Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2013/524701
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.02
dc.relation.issn 1687-479X


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