Universidad Peruana Cayetano Heredia
Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
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| dc.contributor.author | Hernández, Wilfredo | |
| dc.contributor.author | Paz, Juan | |
| dc.contributor.author | Carrasco, Fernando | |
| dc.contributor.author | Vaisberg Wollach, Abraham Jaime | |
| dc.contributor.author | Spodine, Evgenia | |
| dc.contributor.author | Manzur, Jorge | |
| dc.contributor.author | Hennig, Lothar | |
| dc.contributor.author | Sieler, Joachim | |
| dc.contributor.author | Blaurock, Steffen | |
| dc.contributor.author | Beyer, Lothar | |
| dc.date.accessioned | 2019-02-06T14:52:14Z | |
| dc.date.available | 2019-02-06T14:52:14Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5277 | |
| dc.description.abstract | The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes ((IC50 = 0.01–9.87 𝜇M) exhibited higher antiproliferative activity than their free ligands ((IC50 = 23.48–70.86 and >250 𝜇M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 𝜇M, resp.). | en_US |
| dc.language.iso | eng | |
| dc.publisher | Hindawi | |
| dc.relation.ispartofseries | Bioinorganic Chemistry and Applications | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Palladium(II) Thiosemicarbazone | en_US |
| dc.subject | Cytotoxic Activity | en_US |
| dc.subject | Human Tumor Cell Lines | en_US |
| dc.title | Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1155/2013/524701 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.06.03 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.04.01 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.04.02 | |
| dc.relation.issn | 1687-479X |
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