Universidad Peruana Cayetano Heredia

Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats

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dc.contributor.author Brito, Julio
dc.contributor.author Siques, Patricia
dc.contributor.author Arribas, Silvia M.
dc.contributor.author Lopez de Pablo, Angel L.
dc.contributor.author Gonzalez, M. Carmen
dc.contributor.author Naveas, Nelson
dc.contributor.author Arriaza, Karem
dc.contributor.author Flores, Karen
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Pulido, Ruth
dc.contributor.author Ordenes, Stefany
dc.contributor.author Lopez, M. Rosario
dc.date.accessioned 2019-02-06T14:52:14Z
dc.date.available 2019-02-06T14:52:14Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5278
dc.description.abstract Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, n = 10) in a chamber (428 Torr, 4,600 m of altitude) for 46 days and compared to rats under normoxia (NX, n = 10). Body weight, hematocrit, and right ventricle ratio were measured. Pulmonary artery remodeling was assessed using confocal microscopy of tissues stained with a nuclear dye (DAPI) and CD11b antibody. Both hypoxic conditions exhibited increased hematocrit and hypertrophy of the right ventricle, tunica adventitia, and tunica media, with no changes in lumen size. The medial hypertrophy area (larger in CH) depicted a significant increase in smooth muscle cell number. Additionally, CIH2x2 increased the adventitial hypertrophy area, with an increased cellularity and a larger prevalence of clustered inflammatory cells. In conclusion, CIH2x2 elicits milder effects on pulmonary artery medial layer muscularization and subsequent right ventricular hypertrophy than CH. However, CIH2x2 induces greater and characteristic alterations of the adventitial layer. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries BioMed Research International
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Disease Models, Animal en_US
dc.subject Rats en_US
dc.subject Adventitia/pathology/physiopathology en_US
dc.subject Altitude Sickness/pathology/physiopathology en_US
dc.subject Hypoxia/pathology/physiopathology en_US
dc.subject Pulmonary Artery/pathology/physiopathology en_US
dc.subject Vascular Remodeling en_US
dc.subject Rats, Wistar en_US
dc.title Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2015/169841
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 2314-6141


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