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Can a simple test of functional capacity add to the clinical assessment of diabetes?

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dc.contributor.author Stewart, T.
dc.contributor.author Caffrey, D. G.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Mathai, S. C.
dc.contributor.author Lerner, A.
dc.contributor.author Hernandez, A.
dc.contributor.author Pinto, M. E.
dc.contributor.author Huaylinos, Y.
dc.contributor.author Cabrera, L.
dc.contributor.author Wise, R. A.
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Checkley, W.
dc.date.accessioned 2019-02-06T14:52:18Z
dc.date.available 2019-02-06T14:52:18Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5300
dc.description.abstract AIM: To identify impairment in functional capacity associated with complicated and non-complicated diabetes using the 6-min walk distance test. METHODS: We enrolled 111 adults, aged >/=40 years, with Type 2 diabetes from a hospital facility and 150 healthy control subjects of similar age and sex from a community site in Lima, Peru. All participants completed a 6-min walk test. RESULTS: The mean age of the 261 participants was 58.3 years, and 43.3% were male. Among those with diabetes, 67 (60%) had non-complicated diabetes and 44 (40%) had complications such as peripheral neuropathy, retinopathy or nephropathy. The mean unadjusted 6-min walk distances were 376 m and 394 m in adults with and without diabetes complications, respectively, vs 469 m in control subjects (P<0.001). In multivariable regression, the subjects with diabetes complications walked 84 m less far (95% CI -104 to -63 m) and those without complications walked 60 m less far (-77 to -42 m) than did control subjects. When using HbA1c level as a covariate in multivariable regression, participants walked 13 m less far (-16.9 to -9.9 m) for each % increase in HbA1c . CONCLUSIONS: The subjects with diabetes had lower functional capacity compared with healthy control subjects with similar characteristics. Differences in 6-min walk distance were even apparent in the subjects without diabetes complications. Potential mechanisms that could explain this finding are early cardiovascular disease or deconditioning. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Diabetic Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Case-Control Studies en_US
dc.subject Linear Models en_US
dc.subject Multivariate Analysis en_US
dc.subject Walk Test en_US
dc.subject Diabetes Mellitus, Type 2/complications/metabolism/physiopathology en_US
dc.subject Diabetic Nephropathies/etiology en_US
dc.subject Diabetic Neuropathies/etiology en_US
dc.subject Diabetic Retinopathy/etiology en_US
dc.subject Glycated Hemoglobin A/metabolism en_US
dc.title Can a simple test of functional capacity add to the clinical assessment of diabetes? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/dme.13032
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.27
dc.relation.issn 1464-5491


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