Universidad Peruana Cayetano Heredia

Dynamics of nasal carriage of methicillin-resistant Staphylococcus aureus among healthcare workers in a tertiary-care hospital in Peru

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dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Acuna-Villaorduna, A.
dc.contributor.author Dulanto, A.
dc.contributor.author Vandendriessche, S.
dc.contributor.author Hallin, M.
dc.contributor.author Jacobs, J.
dc.contributor.author Denis, O.
dc.date.accessioned 2019-02-06T14:52:19Z
dc.date.available 2019-02-06T14:52:19Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5309
dc.description.abstract The study aims were to describe the frequency and dynamics of methicillin-resistant Staphylococcus aureus (MRSA) carriage among healthcare workers (HCWs), and to compare the molecular epidemiology of MRSA isolates from HCWs with those from patients with bacteremia. HCWs were interviewed and three nasal swabs were collected in a hospital in Lima, Peru, during 2009-2010. Consecutive S. aureus blood culture isolates from patients with bacteremia in the same hospital were also collected. SCCmec, multilocus sequence typing (MLST), and spa typing were performed. Persistent carriage was defined if having at least two consecutive cultures grown with S. aureus harboring an identical spa type. Among 172 HCWs included, the proportions of S. aureus and MRSA nasal carriage during first sampling were 22.7 % and 8.7 %, respectively. From 160 HCWs who were sampled three times, 12.5 % (20/160) were persistent S. aureus carriers and 26.9 % (43/160) were intermittent carriers. MRSA carriage among persistent and intermittent S. aureus carriers was 45.0 % (9/20) and 37.2 % (16/43), respectively. Fifty-six S. aureus blood culture isolates were analyzed, and 50 % (n = 28) were MRSA. Multidrug resistant ST5-spa t149-SCCmec I and ST72-spa t148-SCCmec non-typeable were the two most frequent genotypes detected among HCWs (91.7 %, i.e., 22/24 HCW in whom MRSA was isolated in at least one sample) and patients (24/28, 85.7 %). In conclusion, we found high proportions of MRSA among persistent and intermittent S. aureus nasal carriers among HCWs in a hospital in Lima. They belonged to similar genetic lineages as those recovered from patients with bacteremia. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries European Journal of Clinical Microbiology and Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Tertiary Care Centers en_US
dc.subject Young Adult en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Longitudinal Studies en_US
dc.subject Molecular Epidemiology en_US
dc.subject Health Personnel en_US
dc.subject Bacteremia/epidemiology/microbiology en_US
dc.subject Carrier State/epidemiology/microbiology en_US
dc.subject Methicillin-Resistant Staphylococcus aureus/classification/genetics/isolation & purification en_US
dc.subject Multilocus Sequence Typing en_US
dc.subject Nasal Mucosa/microbiology en_US
dc.subject Staphylococcal Infections/epidemiology/microbiology en_US
dc.subject Staphylococcal Protein A/genetics en_US
dc.title Dynamics of nasal carriage of methicillin-resistant Staphylococcus aureus among healthcare workers in a tertiary-care hospital in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s10096-015-2512-9
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1435-4373


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