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Developmental Effects Determine Submaximal Arterial Oxygen Saturation in Peruvian Quechua

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dc.contributor.author Kiyamu, Melisa
dc.contributor.author Leon-Velarde, Fabiola
dc.contributor.author Rivera-Chira, Maria
dc.contributor.author Elias, Gianpietro
dc.contributor.author Brutsaert, Tom D.
dc.date.accessioned 2019-02-06T14:52:35Z
dc.date.available 2019-02-06T14:52:35Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5319
dc.description.abstract Kiyamu, Melisa, Fabiola Leon-Velarde, Maria Rivera-Chira, Gianpietro Elias, and Tom D. Brutsaert. Developmental effects determine submaximal arterial oxygen saturation in Peruvian Quechua. High Alt Med Biol 16, 138-146, 2015.--Andean high altitude natives show higher arterial oxygen saturation (Sao(2)) during exercise in hypoxia, compared to acclimatized sojourners. In order to evaluate the effects of life-long exposure to high altitude on Sao(2), we studied two groups of well-matched, self-identified Peruvian Quechua natives who differed in their developmental exposure to hypoxia before and after a 2-month training period. Male and female volunteers (18-35 years) were recruited in Lima, Peru (150 m). The two groups were: a) Individuals who were born and raised at sea-level (BSL, n=34) and b) Individuals who were born and raised at high altitude (BHA, n=32), but who migrated to sea-level as adults (>16 years old). Exercise testing was conducted using a submaximal exercise protocol in normobaric hypoxia in Lima (BP=750 mmHg, Fio(2)=0.12), in order to measure Sao(2) (%), ventilation (VE L/min) and oxygen consumption (Vo(2), L/min). Repeated-measures ANOVA, controlling for VE/VO(2) (L/min) and sex during the submaximal protocol showed that BHA maintained higher Sao(2) (%) compared to BSL at all workloads before (p=0.005) and after training (p=0.017). As expected, both groups showed a decrease in Sao(2) (%) (p<0.001), as workload increased. Resting Sao(2) levels were not found to be different between groups. The results suggest that developmental exposure to altitude contributes to the maintenance of higher Sao(2) levels during submaximal exercise at hypoxia. en_US
dc.language.iso eng
dc.publisher Mary Ann Liebert
dc.relation.ispartof urn:issn:1557-8682
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Altitude en_US
dc.subject hypoxia en_US
dc.subject adaptation en_US
dc.subject development en_US
dc.subject Indians, South American en_US
dc.subject Acclimatization/physiology en_US
dc.subject Altitude Sickness/metabolism en_US
dc.subject Exercise Test en_US
dc.subject Oxygen Consumption/physiology en_US
dc.subject Peru/ethnology en_US
dc.subject Pulmonary Gas Exchange/physiology en_US
dc.subject saturation en_US
dc.title Developmental Effects Determine Submaximal Arterial Oxygen Saturation in Peruvian Quechua en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1089/ham.2014.1126
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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