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Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

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dc.contributor.author Vyas, Kaetan J.
dc.contributor.author Danz, David
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Wise, Robert A.
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Checkley, William
dc.date.accessioned 2019-02-06T14:52:35Z
dc.date.available 2019-02-06T14:52:35Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5320
dc.description.abstract Vyas, Kaetan J., David Danz, Robert H. Gilman, Robert A. Wise, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude. High Alt Med Biol 16:162-168, 2015.--Globally, over 140 million people are at risk of developing chronic mountain sickness, a common maladaptation to life at high altitude (>2500 meters above sea level). The diagnosis is contingent upon the identification of excessive erythrocytosis (EE). Current best practices to identify EE require a venous blood draw, which is cumbersome for large-scale surveillance. We evaluated two point-of-care biomarkers to screen for EE: noninvasive spot-check tests of total hemoglobin and oxyhemoglobin saturation (Pronto-7, Masimo Corporation). We conducted paired evaluations of total serum hemoglobin from a venous blood draw and noninvasive, spot-check testing of total hemoglobin and oxyhemoglobin saturation with the Pronto-7 in 382 adults aged >/=35 years living in Puno, Peru (3825 meters above sea level). We used the Bland-Altman method to measure agreement between the noninvasive hemoglobin assessment and the gold standard lab hemoglobin analyzer. Mean age was 58.8 years and 47% were male. The Pronto-7 test was unsuccessful in 21 (5%) participants. Limits of agreement between total hemoglobin measured via venous blood draw and the noninvasive, spot-check test ranged from -2.8 g/dL (95%). en_US
dc.language.iso eng
dc.publisher Mary Ann Liebert
dc.relation.ispartofseries High Altitude Medicine and Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Sensitivity and Specificity en_US
dc.subject chronic mountain sickness en_US
dc.subject Chronic Disease en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Altitude en_US
dc.subject Reproducibility of Results en_US
dc.subject excessive erythrocytosis en_US
dc.subject screening en_US
dc.subject Altitude Sickness/blood/diagnosis en_US
dc.subject Hematologic Tests/instrumentation/statistics & numerical data en_US
dc.subject Hemoglobins/analysis en_US
dc.subject noninvasive methods en_US
dc.subject Point-of-Care Systems/statistics & numerical data en_US
dc.subject Polycythemia/blood en_US
dc.title Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1089/ham.2015.0026
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1557-8682


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