Universidad Peruana Cayetano Heredia

Ambulatory blood pressure in untreated and treated hypertensive patients at high altitude: the High Altitude Cardiovascular Research-Andes study

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dc.contributor.author Bilo, Grzegorz
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Faini, Andrea
dc.contributor.author Anza-Ramirez, Cecilia
dc.contributor.author Revera, Miriam
dc.contributor.author Giuliano, Andrea
dc.contributor.author Caravita, Sergio
dc.contributor.author Gregorini, Francesca
dc.contributor.author Lombardi, Carolina
dc.contributor.author Salvioni, Elisabetta
dc.contributor.author Macarlupu, Jose Luis
dc.contributor.author Ossoli, Deborah
dc.contributor.author Landaveri, Leah
dc.contributor.author Lang, Morin
dc.contributor.author Agostoni, Piergiuseppe
dc.contributor.author Sosa, Jose Manuel
dc.contributor.author Mancia, Giuseppe
dc.contributor.author Parati, Gianfranco
dc.date.accessioned 2019-02-06T14:52:36Z
dc.date.available 2019-02-06T14:52:36Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5322
dc.description.abstract UNLABELLED: Blood pressure increases during acute exposure to high altitude in healthy humans. However, little is known on altitude effects in hypertensive subjects or on the treatment efficacy in this condition. Objectives of High Altitude Cardiovascular Research (HIGHCARE)-Andes Lowlanders Study were to investigate the effects of acute high-altitude exposure on 24-hour ambulatory blood pressure in hypertensive subjects and to assess antihypertensive treatment efficacy in this setting. One hundred untreated subjects with mild hypertension (screening blood pressure, 144.1+/-9.8 mm Hg systolic, 92.0+/-7.5 mm Hg diastolic) were randomized to double-blind placebo or to telmisartan 80 mg+modified release nifedipine 30 mg combination. Twenty-four-hour ambulatory blood pressure monitoring was performed off-treatment, after 6 weeks of treatment at sea level, on treatment during acute exposure to high altitude (3260 m) and immediately after return to sea level. Eighty-nine patients completed the study (age, 56.4+/-17.6 years; 52 men/37 women; body mass index, 28.2+/-3.5 kg/m(2)). Twenty-four-hour systolic blood pressure increased at high altitude in both groups (placebo, 11.0+/-9 mm Hg; P<0.001 and active treatment, 8.1+/-10.4 mm Hg; P<0.001). Active treatment reduced 24-hour systolic blood pressure both at sea level and at high altitude (147.9+/-11.1 versus 132.6+/-12.4 mm Hg for placebo versus treated; P<0.001; 95% confidence interval of the difference 10.9-19.9 mm Hg) and was well tolerated. Similar results were obtained for diastolic, for daytime blood pressure, and for nighttime blood pressure. Treatment was well tolerated in all conditions. Our study demonstrates that (1) 24-hour blood pressure increases significantly during acute high-altitude exposure in hypertensive subjects and (2) treatment with angiotensin receptor blocker-calcium channel blocker combination is effective and safe in this condition. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Hypertension
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Altitude en_US
dc.subject Treatment Outcome en_US
dc.subject Severity of Illness Index en_US
dc.subject Risk Assessment en_US
dc.subject blood pressure en_US
dc.subject altitude en_US
dc.subject Confidence Intervals en_US
dc.subject Double-Blind Method en_US
dc.subject Antihypertensive Agents/therapeutic use en_US
dc.subject Reference Values en_US
dc.subject anoxia en_US
dc.subject antihypertensive agents en_US
dc.subject Blood Pressure Determination/methods en_US
dc.subject blood pressure monitoring, ambulatory en_US
dc.subject Blood Pressure Monitoring, Ambulatory/methods en_US
dc.subject Hypertension/diagnosis/drug therapy en_US
dc.title Ambulatory blood pressure in untreated and treated hypertensive patients at high altitude: the High Altitude Cardiovascular Research-Andes study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1161/HYPERTENSIONAHA.114.05003
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.relation.issn 1524-4563


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