Universidad Peruana Cayetano Heredia

Chronic exposure to biomass fuel smoke and markers of endothelial inflammation

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dc.contributor.author Caravedo, M. A.
dc.contributor.author Herrera, P. M.
dc.contributor.author Mongilardi, N.
dc.contributor.author de Ferrari, A.
dc.contributor.author Davila-Roman, V. G.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Wise, R. A.
dc.contributor.author Miele, C. H.
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Checkley, W.
dc.date.accessioned 2019-02-06T14:52:36Z
dc.date.available 2019-02-06T14:52:36Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5325
dc.description.abstract Indoor smoke exposure may affect cardiovascular disease (CVD) risk via lung-mediated inflammation, oxidative stress, and endothelial inflammation. We sought to explore the association between indoor smoke exposure from burning biomass fuels and a selected group of markers for endothelial inflammation. We compared serum concentrations of amyloid A protein, E-selectin, soluble intercellular adhesion molecule 1 (ICAM-1) and VCAM-1, von Willebrand factor (vWF), and high-sensitivity C-reactive protein (hs-CRP) in 228 biomass-exposed vs. 228 non-exposed participants living in Puno, Peru. Average age was 56 years (s.d. = 13), average BMI was 26.5 kg/m(2) (s.d. = 4.4), 48% were male, 59.4% completed high school, and 2% reported a physician diagnosis of CVD. In unadjusted analysis, serum levels of soluble ICAM-1 (330 vs. 302 ng/ml; P < 0.001), soluble VCAM-1 (403 vs. 362 ng/ml; P < 0.001), and E-selectin (54.2 vs. 52.7 ng/ml; P = 0.05) were increased in biomass-exposed vs. non-exposed participants, respectively, whereas serum levels of vWF (1148 vs. 1311 mU/ml; P < 0.001) and hs-CRP (2.56 vs. 3.12 mg/l; P < 0.001) were decreased, respectively. In adjusted analyses, chronic exposure to biomass fuels remained positively associated with serum levels of soluble ICAM-1 (P = 0.03) and VCAM-1 (P = 0.05) and E-selectin (P = 0.05), and remained negatively associated with serum levels of vWF (P = 0.02) and hs-CRP (P < 0.001). Daily exposure to biomass fuel smoke was associated with important differences in specific biomarkers of endothelial inflammation and may help explain accelerated atherosclerosis among those who are chronically exposed. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Indoor Air
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Case-Control Studies en_US
dc.subject Risk Factors en_US
dc.subject Epidemiology en_US
dc.subject Air Pollution, Indoor/adverse effects en_US
dc.subject Biomass en_US
dc.subject Environmental Exposure/adverse effects en_US
dc.subject Biomarkers/blood en_US
dc.subject C-Reactive Protein/analysis en_US
dc.subject Smoke/adverse effects en_US
dc.subject Biomass fuel exposure en_US
dc.subject Cardiovascular disease en_US
dc.subject Endothelial inflammation biomarkers en_US
dc.subject Household air pollution en_US
dc.subject Rural communities en_US
dc.subject Biofuels/toxicity en_US
dc.subject Cardiovascular Diseases/etiology en_US
dc.subject E-Selectin/blood en_US
dc.subject Inflammation/blood/etiology en_US
dc.subject Intercellular Adhesion Molecule-1/blood en_US
dc.subject Serum Amyloid A Protein/analysis en_US
dc.subject Vascular Cell Adhesion Molecule-1/blood en_US
dc.subject von Willebrand Factor/analysis en_US
dc.title Chronic exposure to biomass fuel smoke and markers of endothelial inflammation en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/ina.12259
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#2.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1600-0668


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