Universidad Peruana Cayetano Heredia

Brucellosis in pregnancy: clinical aspects and obstetric outcomes

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dc.contributor.author Vilchez, Gustavo
dc.contributor.author Espinoza, Miguel
dc.contributor.author D'Onadio, Guery
dc.contributor.author Saona, Pedro
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2019-02-06T14:52:37Z
dc.date.available 2019-02-06T14:52:37Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5329
dc.description.abstract OBJECTIVE: Brucellosis is a zoonosis with high morbidity in humans. This disease has gained interest recently due to its re-emergence and potential for weaponization. Pregnant women with this disease can develop severe complications. Its association with adverse obstetric outcomes is not clearly understood. The objective of this study was to describe the obstetric outcomes of brucellosis in pregnancy. METHODS: Cases of pregnant women with active brucellosis seen at the Hospital Nacional Cayetano Heredia from 1970 to 2012 were reviewed. Diagnostic criteria were a positive agglutination test and/or positive blood/bone marrow culture. Presentation and outcomes data were collected. The Chi-square test was used for nominal variables. A p-value of <0.05 indicated significance. RESULTS: One hundred and one cases were included; 27.7% had a threatened abortion/preterm labor, 12.8% experienced spontaneous abortion, 13.9% preterm delivery, 8.1% fetal death, and 1.1% congenital malformations. There was one maternal death secondary to severe sepsis. After delivery, neonatal death occurred in 8.1%, low birth weight in 14.5%, and congenital brucellosis in 6.4%. The most common treatment was aminoglycosides plus rifampicin (42.2% of cases). Complication rates decreased if treatment was started within 2 weeks of presentation (p < 0.001). CONCLUSIONS: This is the largest series of brucellosis in pregnancy reported in the literature. Brucella presents adverse obstetric outcomes including fetal and maternal/neonatal death. Cases with unexplained spontaneous abortion should be investigated for brucellosis. Prompt treatment is paramount to decrease the devastating outcomes. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Middle Aged en_US
dc.subject Animals en_US
dc.subject Pregnancy en_US
dc.subject Delivery, Obstetric en_US
dc.subject Infant, Newborn en_US
dc.subject Infant, Low Birth Weight en_US
dc.subject Pregnancy Complications, Infectious/diagnosis/drug therapy en_US
dc.subject Pregnancy Outcome en_US
dc.subject Abortion, Spontaneous/epidemiology en_US
dc.subject Brucellosis en_US
dc.subject Brucellosis/complications/diagnosis/drug therapy en_US
dc.subject Fetal death en_US
dc.subject Fetal Death en_US
dc.subject Maternal death en_US
dc.subject Maternal Death en_US
dc.subject Neonatal death en_US
dc.subject Obstetric Labor, Premature/epidemiology en_US
dc.subject Premature Birth/epidemiology en_US
dc.subject Preterm labor en_US
dc.title Brucellosis in pregnancy: clinical aspects and obstetric outcomes en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2015.06.027
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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