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Social network analysis identified central outcomes for core outcome sets using systematic reviews of HIV/AIDS

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dc.contributor.author Saldanha, Ian J.
dc.contributor.author Li, Tianjing
dc.contributor.author Yang, Cui
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Rutherford, George W.
dc.contributor.author Dickersin, Kay
dc.date.accessioned 2019-02-06T14:52:38Z
dc.date.available 2019-02-06T14:52:38Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5339
dc.description.abstract OBJECTIVES: Methods to develop core outcome sets, the minimum outcomes that should be measured in research in a topic area, vary. We applied social network analysis methods to understand outcome co-occurrence patterns in human immunodeficiency virus (HIV)/AIDS systematic reviews and identify outcomes central to the network of outcomes in HIV/AIDS. STUDY DESIGN AND SETTING: We examined all Cochrane reviews of HIV/AIDS as of June 2013. We defined a tie as two outcomes (nodes) co-occurring in >/=2 reviews. To identify central outcomes, we used normalized node betweenness centrality (nNBC) (the extent to which connections between other outcomes in a network rely on that outcome as an intermediary). We conducted a subgroup analysis by HIV/AIDS intervention type (i.e., clinical management, biomedical prevention, behavioral prevention, and health services). RESULTS: The 140 included reviews examined 1,140 outcomes, 294 of which were unique. The most central outcome overall was all-cause mortality (nNBC = 23.9). The most central and most frequent outcomes differed overall and within subgroups. For example, "adverse events (specified)" was among the most central but not among the most frequent outcomes, overall. CONCLUSION: Social network analysis methods are a novel application to identify central outcomes, which provides additional information potentially useful for developing core outcome sets. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Clinical Epidemiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject HIV/AIDS en_US
dc.subject Randomized controlled trials en_US
dc.subject Outcome Assessment (Health Care) en_US
dc.subject Review Literature as Topic en_US
dc.subject Social Support en_US
dc.subject Acquired Immunodeficiency Syndrome/epidemiology/mortality en_US
dc.subject Core outcome sets en_US
dc.subject HIV Infections/epidemiology/mortality en_US
dc.subject Outcomes en_US
dc.subject Social network analysis en_US
dc.subject Systematic reviews en_US
dc.title Social network analysis identified central outcomes for core outcome sets using systematic reviews of HIV/AIDS en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jclinepi.2015.08.023
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn 1878-5921


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